SCHEMBL15964871

SCHEMBL15964871

O=C(Cl)Oc1ccc(Cl)cc1-c1nc2ccc(Cl)cc2c(=O)[nH]1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNKS O95271 2/20 0.50
TNKS2 Q9H2K2 2/20 0.50
PARP1 P09874 2/20 0.50
GUSB P08236 4/20 0.49
KDM4E B2RXH2 2/20 0.46
CYP1A1 P04798 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP1B1 Q16678 1/20 0.44
TUBB4A P04350 2/20 0.43
TUBB P07437 2/20 0.43
TUBA3C P0DPH7 2/20 0.43
TUBA1B P68363 2/20 0.43
TUBA4A P68366 2/20 0.43
TUBB4B P68371 2/20 0.43
TUBB3 Q13509 2/20 0.43
TUBB2A Q13885 2/20 0.43
TUBB8 Q3ZCM7 2/20 0.43
TUBA3E Q6PEY2 2/20 0.43
TUBA1A Q71U36 2/20 0.43
TUBA1C Q9BQE3 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13953178 0.84 AMY1A (0.57) TNKSTNKS2PARP1GUSBKDM4E
SCHEMBL13932609 0.83 TNKS (0.50) TNKSTNKS2PARP1GUSBKDM4E
SCHEMBL18627093 0.82 HPGD (0.51) TNKSTNKS2PARP1GUSBKDM4E
SCHEMBL1461063 0.82 GUSB (0.51) TNKSTNKS2PARP1GUSBKDM4E
SCHEMBL1232936 0.82 TNKS (0.49) TNKSTNKS2PARP1GUSBKDM4E
SCHEMBL29351150 0.82 TNKS (0.49) TNKSTNKS2PARP1GUSBKDM4E
SCHEMBL23732260 0.81 TNKS (0.57) TNKSTNKS2PARP1GUSBKDM4E
Ammonia Solution, Strong SCHEMBL9010817 0.81 GUSB (0.50) TNKSTNKS2PARP1GUSBKDM4E
SCHEMBL3660038 0.81 TNKS (0.48) TNKSTNKS2PARP1GUSBKDM4E
Ammonia Solution, Strong SCHEMBL9010745 0.81 TNKS (0.48) TNKSTNKS2PARP1GUSBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240156965-A1 DICHALCOGENIDE PRODRUGS LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) 2024-05-16 US disclosed
EP-4320124-A1 DICHALCOGENIDE PRODRUGS Ludwig-Maximilians-Universität München (DE) 2024-02-14 EP disclosed
WO-2022214598-A1 DICHALCOGENIDE PRODRUGS LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2022-10-13 WO disclosed
EP-4071148-A1 DICHALCOGENIDE PRODRUGS Ludwig-Maximilians-Universität München (DE) 2022-10-12 EP disclosed
US-11078226-B2 Fluorogenic glycosidase substrate and associated detection method ECOLE NORMALE SUPERIEURE DE LYON (FR) 2021-08-03 US disclosed
WO-2018114933-A1 FLUOROGENIC GLYCOSIDASE SUBSTRATE AND ASSOCIATED DETECTION METHOD ECOLE NORMALE SUPERIEURE DE LYON (FR) 2018-06-28 WO disclosed
US-9605296-B2 Fluorogenic peptidase substrate ECOLE NORMALE SUPERIEURE DE LYON (FR) 2017-03-28 US disclosed
US-9605296-B2 Fluorogenic peptidase substrate ECOLE NORMALE SUPERIEURE DE LYON (FR) 2017-03-28 US disclosed
US-9593362-B2 Fluorogenic glycosidase substrate and associated detection method ECOLE NORMALE SUPERIEURE DE LYON (FR) 2017-03-14 US disclosed
US-9593362-B2 Fluorogenic glycosidase substrate and associated detection method ECOLE NORMALE SUPERIEURE DE LYON (FR) 2017-03-14 US disclosed
US-20150299762-A1 FLUOROGENIC GLYCOSIDASE SUBSTRATE AND ASSOCIATED DETECTION METHOD ECOLE NORMALE SUPERIEURE DE LYON (FR) 2015-10-22 US disclosed
US-20150299762-A1 FLUOROGENIC GLYCOSIDASE SUBSTRATE AND ASSOCIATED DETECTION METHOD ECOLE NORMALE SUPERIEURE DE LYON (FR) 2015-10-22 US disclosed
US-20140234887-A1 FLUOROGENIC PEPTIDASE SUBSTRATE CENTRE NATIONAL DE LA RECHERCHE SCIENTFIQUE (FR) 2014-08-21 US disclosed
US-20140234887-A1 FLUOROGENIC PEPTIDASE SUBSTRATE CENTRE NATIONAL DE LA RECHERCHE SCIENTFIQUE (FR) 2014-08-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240156965-A1 DICHALCOGENIDE PRODRUGS DHCR7, DECR1, CYP27A1 TNKS 4258/4885TNKS2 4271/4885PARP1 3105/4885
US-20150299762-A1 FLUOROGENIC GLYCOSIDASE SUBSTRATE AND ASSOCIATED DETECTION METHOD MAN2B1, FUCA1, NEU1 TNKS 2968/4885TNKS2 3270/4885PARP1 2148/4885
US-11078226-B2 Fluorogenic glycosidase substrate and associated detection method GBA3, ENGASE, RNASE1 TNKS 2541/4885TNKS2 2987/4885PARP1 2721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.