Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2225370 | 0.88 | S1PR1 (0.58) | S1PR1KDM4ENPC1HSD17B10RAB9A | |
| SCHEMBL14796985 | 0.83 | S1PR1 (0.57) | S1PR1KDM4ENPC1HSD17B10RAB9A | |
| SCHEMBL2225306 | 0.81 | S1PR1 (0.54) | S1PR1ALOX5HSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL2221033 | 0.80 | S1PR1 (0.49) | S1PR1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL2222684 | 0.80 | S1PR1 (0.48) | S1PR1ALOX5TP53LMNAMAPT | |
| SCHEMBL2228763 | 0.77 | S1PR1 (0.64) | S1PR1KDM4ENPC1HSD17B10RAB9A | |
| SCHEMBL15966896 | 0.77 | S1PR1 (0.52) | S1PR1KDM4EHSD17B10RAB9AALDH1A1 | |
| SCHEMBL2223451 | 0.76 | S1PR1 (0.45) | S1PR1GAAKMT2A | |
| SCHEMBL2224650 | 0.74 | S1PR1 (0.58) | S1PR1KDM4ENPC1HSD17B10RAB9A | |
| SCHEMBL2223368 | 0.74 | S1PR1 (0.83) | S1PR1KDM4EHSD17B10ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040544-B2 | 2,5-substituted oxazolopyrimidine derivatives | SANOFI (FR) | 2015-05-26 | — | — | US | claimed |
| EP-2523963-B1 | 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES AS EDG-1 AGONISTS | SANOFI SA (FR) | 2014-08-27 | — | — | EP | disclosed |