Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1683544 | 0.82 | ALDH1A1 (0.40) | TSHRTHRBALDH1A1KDM4ETDP1 | |
| SCHEMBL2743760 | 0.80 | TSHR (0.41) | TSHRTHRBALDH1A1KDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL2831036 | 0.80 | TSHR (0.38) | TSHRTHRBALDH1A1KDM4ETDP1 | |
| Fluoride Ion SCHEMBL29161106 | 0.79 | TSHR (0.40) | TSHRTHRBALDH1A1KDM4ETDP1 | |
| Iodide SCHEMBL29161127 | 0.79 | TSHR (0.40) | TSHRTHRBALDH1A1KDM4ETDP1 | |
| Bromide SCHEMBL28360563 | 0.79 | TSHR (0.40) | TSHRTHRBALDH1A1KDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL27707282 | 0.78 | THRB (0.45) | TSHRTHRBALDH1A1KDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL28311399 | 0.77 | ALDH1A1 (0.38) | TSHRTHRBALDH1A1KDM4ETDP1 | |
| SCHEMBL5467970 | 0.77 | TSHR (0.51) | TSHRTHRBALDH1A1CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL16020739 | 0.76 | TSHR (0.55) | TSHRTHRBALDH1A1CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140242195-A1 | AUTOMOTIVE SURFACE CONDITIONING SYSTEM | AMERICAN COVERS, INC. (US) | 2014-08-28 | — | — | US | disclosed |
| WO-2014130369-A1 | AUTOMOTIVE SURFACE CONDITIONING SYSTEM | AMERICAN COVERS, INC. (US) | 2014-08-28 | — | — | WO | disclosed |