Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CTSV | O60911 | 3/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.52 |
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | RXRG | P48443 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30442197 | 0.94 | FOLH1 (0.55) | FOLH1MRGPRX4NPC1CTSVCTSL | |
| SCHEMBL25298462 | 0.94 | FOLH1 (0.55) | FOLH1MRGPRX4NPC1CTSVCTSL | |
| SCHEMBL4464916 | 0.92 | FOLH1 (0.56) | FOLH1MRGPRX4NPC1CTSVCTSL | |
| SCHEMBL16585652 | 0.91 | FOLH1 (0.58) | FOLH1MRGPRX4NPC1CTSVCTSL | |
| SCHEMBL30261516 | 0.87 | MRGPRX4 (0.60) | FOLH1MRGPRX4NPC1PTGER1MCL1 | |
| SCHEMBL582711 | 0.84 | FOLH1 (0.51) | FOLH1MRGPRX4NPC1CTSVCTSL | |
| SCHEMBL31197229 | 0.84 | MRGPRX4 (0.64) | FOLH1MRGPRX4NPC1CTSVCTSL | |
| SCHEMBL31056459 | 0.83 | FOLH1 (0.45) | FOLH1MRGPRX4NPC1CTSVCTSL | |
| SCHEMBL662496 | 0.82 | NPC1 (0.46) | FOLH1MRGPRX4NPC1CTSVCTSL | |
| SCHEMBL19667234 | 0.82 | FOLH1 (0.56) | FOLH1MRGPRX4NPC1CTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133129-B2 | Bicyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-09-15 | — | — | US | disclosed |
| EP-2772485-A1 | BICYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2014-09-03 | — | — | EP | disclosed |
| US-20140243310-A1 | BICYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-08-28 | — | — | US | disclosed |
| CN-103998432-A | Bicyclic compounds | TAKEDA PHARMACEUTICAL | 2014-08-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243310-A1 | BICYCLIC COMPOUND | BICRA, NR3C2, CYP11B2 | FOLH1 2011/4885MRGPRX4 1167/4885NPC1 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.