Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.49 |
| ▸ | CTSV | O60911 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30442197 | 0.87 | FOLH1 (0.55) | FOLH1MRGPRX4NPC1PTGER1CTSV | |
| SCHEMBL25298462 | 0.87 | FOLH1 (0.55) | FOLH1MRGPRX4NPC1PTGER1CTSV | |
| SCHEMBL11922623 | 0.87 | NPC1 (0.49) | MRGPRX4NPC1CTSVCTSLKDM4E | |
| SCHEMBL5064933 | 0.85 | BRD4 (0.47) | FOLH1MRGPRX4NPC1PTGER1CTSV | |
| SCHEMBL2684149 | 0.84 | ALDH1A1 (0.49) | MRGPRX4NPC1ALDH1A1BRD4LMNA | |
| SCHEMBL4220259 | 0.84 | MCL1 (0.54) | FOLH1PTGER1MCL1KDM4EALDH1A1 | |
| SCHEMBL16585652 | 0.84 | FOLH1 (0.58) | FOLH1MRGPRX4NPC1PTGER1CTSV | |
| SCHEMBL15968165 | 0.84 | FOLH1 (0.55) | FOLH1MRGPRX4NPC1PTGER1CTSV | |
| SCHEMBL7430696 | 0.83 | LTA4H (0.49) | MRGPRX4NPC1PTGER1L3MBTL1S1PR5 | |
| SCHEMBL20400911 | 0.83 | FOLH1 (0.55) | FOLH1MRGPRX4NPC1PTGER1CTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417130-A2 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND VARIOUS THERAPEUTIC USES THEREOF | SANOFI (FR) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010116088-A2 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND VARIOUS THERAPEUTIC USES THEREOF | SANOFI-AVENTIS (FR) | 2010-10-14 | — | — | WO | disclosed |