Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.59 |
| ▸ | RAB9A | P51151 | 14/20 | 0.59 |
| ▸ | NPC1 | O15118 | 13/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 11/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.57 |
| ▸ | MEN1 | O00255 | 9/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.57 |
| ▸ | MITF | O75030 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15972778 | 1.00 | MAPT (0.59) | MAPTRAB9ANPC1L3MBTL1TDP1 | |
| SCHEMBL4172201 | 0.84 | MAPT (0.70) | MAPTRAB9ANPC1L3MBTL1TDP1 | |
| SCHEMBL4172197 | 0.84 | MAPT (0.70) | MAPTRAB9ANPC1L3MBTL1TDP1 | |
| SCHEMBL4747962 | 0.78 | CA1 (0.64) | MAPTRAB9ANPC1L3MBTL1TDP1 | |
| SCHEMBL4747964 | 0.78 | CA1 (0.64) | MAPTRAB9ANPC1L3MBTL1TDP1 | |
| SCHEMBL10335995 | 0.77 | MAPT (0.74) | MAPTRAB9ANPC1TDP1GAA | |
| SCHEMBL15972484 | 0.77 | MPO (0.63) | MAPTRAB9ANPC1TDP1GAA | |
| SCHEMBL15972482 | 0.77 | MPO (0.63) | MAPTRAB9ANPC1TDP1GAA | |
| SCHEMBL14563274 | 0.76 | TRPV1 (0.56) | MAPTRAB9ANPC1L3MBTL1GAA | |
| SCHEMBL9520101 | 0.75 | MAPT (0.59) | MAPTRAB9ANPC1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10322125-B2 | TGF-beta enhancing compositions for cartilage repair and methods related thereto | EMORY UNIVERSITY (US) | 2019-06-18 | — | — | US | claimed |
| US-20150374694-A1 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2015-12-31 | — | — | US | claimed |
| WO-2014130411-A9 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2014-10-16 | — | — | WO | claimed |
| WO-2014130411-A1 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2014-08-28 | — | — | WO | claimed |
| US-10322125-B2 | TGF-beta enhancing compositions for cartilage repair and methods related thereto | EMORY UNIVERSITY (US) | 2019-06-18 | — | — | US | disclosed |
| US-20150374694-A1 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2015-12-31 | — | — | US | disclosed |
| WO-2014130411-A9 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014130411-A1 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2014-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150374694-A1 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | COL2A1, TGFB1, TGFBR1 | MAPT 4307/4885RAB9A 3642/4885NPC1 4578/4885 |
| US-10322125-B2 | TGF-beta enhancing compositions for cartilage repair and methods related thereto | COL2A1, TGFB1, TGFBR1 | MAPT 4307/4885RAB9A 3642/4885NPC1 4578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.