Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 7/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 7/20 | 0.47 |
| ▸ | SI | P14410 | 7/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 7/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 3/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15973672 | 0.90 | KCNMA1 (0.54) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL15972715 | 0.89 | MGAM (0.43) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL17910001 | 0.80 | SLC9A1 (0.49) | BRD4SLC9A1KMT2AALDH1A1CTSD | |
| SCHEMBL15973817 | 0.79 | KCNMA1 (0.50) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL17909970 | 0.71 | TDO2 (0.54) | KCNMA1HPGDSLC9A1KMT2AALDH1A1 | |
| SCHEMBL10428645 | 0.71 | GAA (0.67) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL170673 | 0.70 | GAA (0.71) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL7646751 | 0.70 | GAA (0.44) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL15973382 | 0.69 | MCL1 (0.50) | MCL1MGLL | |
| SCHEMBL15973746 | 0.69 | MCL1 (0.50) | MCL1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019482-A2 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2016-05-18 | — | — | EP | disclosed |
| WO-2014128669-A2 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-08-28 | — | — | WO | disclosed |