Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | GAA | P10253 | 5/20 | 0.58 |
| ▸ | MAOB | P27338 | 3/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13875561 | 0.85 | NOX1 (0.61) | MAPTSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL10335995 | 0.81 | MAPT (0.74) | MAPTSMN1; SMN2RAB9AGAAMAOB | |
| SCHEMBL15972471 | 0.78 | MAPT (0.62) | MAPTSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL15972470 | 0.78 | MAPT (0.62) | MAPTSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL10335993 | 0.77 | MAPT (0.67) | MAPTSMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL379196 | 0.74 | MAPT (0.57) | MAPTSMN1; SMN2RAB9AGAAMAOB | |
| SCHEMBL16224307 | 0.72 | GRIN2D (0.46) | MAPTSMN1; SMN2RAB9AGAAMAOB | |
| SCHEMBL27912119 | 0.71 | MAPT (0.64) | MAPTSMN1; SMN2RAB9AGAAMAOB | |
| SCHEMBL27912123 | 0.71 | MAPT (0.64) | MAPTSMN1; SMN2RAB9AGAAMAOB | |
| Hydrochloric Acid SCHEMBL19434720 | 0.71 | GRIN2D (0.47) | MAPTSMN1; SMN2RAB9AGAAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10322125-B2 | TGF-beta enhancing compositions for cartilage repair and methods related thereto | EMORY UNIVERSITY (US) | 2019-06-18 | — | — | US | claimed |
| US-20150374694-A1 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2015-12-31 | — | — | US | claimed |
| WO-2014130411-A9 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2014-10-16 | — | — | WO | claimed |
| WO-2014130411-A1 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2014-08-28 | — | — | WO | claimed |
| US-10322125-B2 | TGF-beta enhancing compositions for cartilage repair and methods related thereto | EMORY UNIVERSITY (US) | 2019-06-18 | — | — | US | disclosed |
| US-20150374694-A1 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2015-12-31 | — | — | US | disclosed |
| WO-2014130411-A9 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014130411-A1 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2014-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150374694-A1 | TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO | COL2A1, TGFB1, TGFBR1 | MAPT 4307/4885SMN1; SMN2 3772/4885RAB9A 3642/4885 |
| US-10322125-B2 | TGF-beta enhancing compositions for cartilage repair and methods related thereto | COL2A1, TGFB1, TGFBR1 | MAPT 4307/4885SMN1; SMN2 3772/4885RAB9A 3642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.