SCHEMBL379196

SCHEMBL379196

N#CC=NNc1cccc(Cl)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 9/20 0.57
SMN1; SMN2 Q16637 6/20 0.57
MEN1 O00255 6/20 0.57
KMT2A Q03164 6/20 0.57
TDP1 Q9NUW8 3/20 0.57
CYP3A4 P08684 2/20 0.57
ALOX15 P16050 2/20 0.57
HSD17B10 Q99714 2/20 0.57
TSHR P16473 1/20 0.57
CISD1 Q9NZ45 1/20 0.57
GAA P10253 7/20 0.53
RAB9A P51151 2/20 0.53
LMNA P02545 4/20 0.46
HTT P42858 3/20 0.46
ALDH1A1 P00352 5/20 0.44
CYP1A2 P05177 2/20 0.44
CYP2D6 P10635 2/20 0.44
CYP2C19 P33261 2/20 0.44
RECQL P46063 2/20 0.44
NPC1 O15118 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2143888 0.78 MAPT (0.46) MAPTSMN1; SMN2MEN1KMT2ATDP1
SCHEMBL2464115 0.77 NOX1 (0.52) MAPTSMN1; SMN2MEN1KMT2ATDP1
SCHEMBL28481154 0.77 CHRM2 (0.46) MAPTSMN1; SMN2MEN1KMT2ATDP1
SCHEMBL14199481 0.77 MAPT (0.61) MAPTSMN1; SMN2MEN1KMT2ATDP1
SCHEMBL15973455 0.74 MAPT (0.58) MAPTSMN1; SMN2MEN1KMT2ATDP1
Carbonyl Cyanide M-Chlorophenylhydrazone SCHEMBL379195 0.72 MAPT (1.00) MAPTSMN1; SMN2MEN1KMT2ATDP1
Carbonyl Cyanide M-Chlorophenylhydrazone SCHEMBL29353613 0.72 MAPT (1.00) MAPTSMN1; SMN2MEN1KMT2ATDP1
SCHEMBL10335995 0.72 MAPT (0.74) MAPTSMN1; SMN2MEN1KMT2ATDP1
SCHEMBL4184589 0.71 MAPT (0.55) MAPTSMN1; SMN2MEN1KMT2ATDP1
SCHEMBL30360229 0.71 MAPT (0.55) MAPTSMN1; SMN2MEN1KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1344 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122060811-A Method for producing agricultural tryptophan by fermentation and application thereof 烟台泓源生物肥料有限公司 2026-05-19 CN claimed
US-20260076969-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2026-03-19 US claimed
WO-2025215232-A1 A COMPOSITION COMPRISING A SAPONIN AND/OR AN ANTHELMINTIC AND/OR A MITOCHONDRIAL UNCOUPLER FOR THE TREATMENT OF LIVER DISEASE RAINCASTLE BIO. LIMITED (GB) 2025-10-16 WO claimed
US-20240190865-A1 T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-06-13 US claimed
WO-2024081653-A2 METHODS OF LOWERING MIRO2 TO TREAT NEURODEGENERATIVE DISEASES ACUREX BIOSCIENCES CORPORATION (US) 2024-04-18 WO claimed
EP-4301759-A2 T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF The Board of Trustees of the Leland Stanford Junior University (US) 2024-01-10 EP claimed
US-11579152-B2 Engineered hERG channel proteins, vesicles and methods of identifying small molecule pharmacological agents THE ROCKEFELLER UNIVERSITY (US) 2023-02-14 US claimed
US-20220389067-A1 Methods of Treating Neurodegenerative Diseases Caused by G4C2 Expansion in C9ORF72 THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2022-12-08 US claimed
WO-2022216386-A9 T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2022-12-01 WO claimed
WO-2022216386-A2 T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2022-10-13 WO claimed
WO-2000006143-A1 CHEMICALLY INDUCED INTRACELLULAR HYPERTHERMIA TEXAS PHARMACEUTICALS, INC. (US) 2000-02-10 WO claimed
US-5994138-A CONTAINS A STAIN CAPABLE OF LABELLING CELLS AFTER INCUBATION, AS WELL AS AN ADDITIVE WHICH IS ABLE TO ENCOURAGE PENETRATION OF THE STAIN INTO THE CELLS, THIS ADDITIVE BEING CHOSEN FROM AN IONOPHORIC COMPOUND, A DETERGENT AND MIXTURES THEREOF ABX (FR) 1999-11-30 US claimed
WO-1999059597-A1 IONOPHORE CONTAINING COMPOSITION FOR MODULATING AMYLOIDOSIS THE UNIVERSITY OF BRITISH COLUMBIA (CA) 1999-11-25 WO claimed
US-5981168-A Method and composition for modulating amyloidosis THE UNIVERSITY OF BRITISH COLUMBIA (CA) 1999-11-09 US claimed
EP-0856735-A1 Colour staining reagent for blood cells ABX (FR) 1998-08-05 EP claimed
EP-0538302-B1 REDUCTION OR PREVENTION OF SKIN IRRITATION BY DRUGS ALZA CORP (US) 1995-04-26 EP claimed
EP-0538302-A1 REDUCTION OR PREVENTION OF SKIN IRRITATION BY DRUGS. ALZA CORP (US) 1993-04-28 EP claimed
US-5160741-A Coadministering transdermally a time-release weak base drug and a lysosomal uptake inhibiting agent ALZA CORPORATION (US) 1992-11-03 US claimed
US-5130139-A Coadministering lysosomac uptake inhibiting agent ALZA CORPORATION (US) 1992-07-14 US claimed
WO-1992000746-A1 REDUCTION OR PREVENTION OF SKIN IRRITATION BY DRUGS ALZA CORPORATION (US) 1992-01-23 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240190865-A1 T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF CACNA1G, CACNA1H, CACNB2 MAPT 3351/4885SMN1; SMN2 3149/4885MEN1 1661/4885
US-20260076969-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER ATP5ME, MT-ATP6, ATP5MK MAPT 4765/4885SMN1; SMN2 3552/4885MEN1 4341/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.