Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.57 |
| ▸ | FEN1 | P39748 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832503 | 0.84 | ALDH1A1 (0.62) | ERCC5FEN1ALDH1A1POLBNPC1 | |
| SCHEMBL31419978 | 0.81 | TSHR (0.59) | ERCC5FEN1ALDH1A1POLBNPC1 | |
| Hydrochloric Acid SCHEMBL31419986 | 0.80 | TSHR (0.61) | ERCC5FEN1ALDH1A1POLBNPC1 | |
| SCHEMBL15973791 | 0.79 | ALDH1A1 (0.47) | ERCC5FEN1ALDH1A1POLBNPC1 | |
| SCHEMBL11316585 | 0.77 | ALDH1A1 (0.58) | ERCC5FEN1ALDH1A1POLBNPC1 | |
| SCHEMBL1923026 | 0.74 | ERCC5 (0.59) | ERCC5FEN1ALDH1A1POLBNPC1 | |
| SCHEMBL13044823 | 0.74 | LMNA (0.69) | ERCC5FEN1ALDH1A1POLBNPC1 | |
| SCHEMBL471019 | 0.74 | ALDH1A1 (0.69) | ERCC5FEN1ALDH1A1POLBNPC1 | |
| SCHEMBL1232758 | 0.74 | — | — | |
| SCHEMBL16597337 | 0.73 | KMT2A (0.59) | ALDH1A1POLBNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2958897-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014130582-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2014-08-28 | — | — | WO | disclosed |