Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.55 |
| ▸ | WNT3A | P56704 | 4/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3303 | 0.98 | ALDH1A1 (0.67) | ALDH1A1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL13044823 | 0.89 | LMNA (0.69) | ALDH1A1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL12719803 | 0.88 | LMNA (0.67) | ALDH1A1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL13536701 | 0.86 | ALDH1A1 (0.65) | ALDH1A1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL14878250 | 0.85 | LMNA (0.62) | ALDH1A1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL14139292 | 0.85 | ALDH1A1 (0.62) | ALDH1A1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL5021506 | 0.85 | LMNA (0.62) | ALDH1A1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL13562555 | 0.83 | LMNA (0.61) | ALDH1A1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL28800151 | 0.83 | ALDH1A1 (0.61) | ALDH1A1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL13536765 | 0.83 | ALDH1A1 (0.61) | ALDH1A1LMNAKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 254 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111979207-A | Aldehyde ketone reductase and method for preparing chiral duloxetine intermediate by asymmetric reduction | 华侨大学 | 2020-11-24 | — | — | CN | claimed |
| EP-2329013-B1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE | CODEXIS INC (US) | 2015-10-28 | — | — | EP | claimed |
| US-8426178-B2 | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine | CODEXIS, INC. (US) | 2013-04-23 | — | — | US | claimed |
| US-20100151534-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE | CODEXIS, INC. (US) | 2010-06-17 | — | — | US | claimed |
| US-20090123514-A1 | Electropolymerizable Monomers and Polymeric Coatings on Implantable Devices Prepared Therefrom | ELUTEX LTD. (IL) | 2009-05-14 | — | — | US | claimed |
| US-20090012315-A1 | Process for Pure Duloxetine Hydrochloride | MSN LABORATORIES LIMITED (IN) | 2009-01-08 | — | — | US | claimed |
| US-20080015362-A1 | Process for the preparation of optically active (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine | TEVA PHARMACEUTICALS USA, INC. | 2008-01-17 | — | — | US | claimed |
| US-20070281989-A1 | Process for preparing duloxetine and intermediates thereof | TEVA PHARMACEUTICALS USA, INC. | 2007-12-06 | — | — | US | claimed |
| CN-1304360-C | Preparation method of N,N-dimethyl-3-hydroxy-3-aryl propyl amine | UNIV TIANJIN (CN) | 2007-03-14 | — | — | CN | claimed |
| EP-0457559-A2 | Chiral synthesis of 1-aryl-3-aminopropan-1-ols | ELI LILLY AND COMPANY (US) | 1991-11-21 | — | — | EP | claimed |
| US-12398126-B2 | Process to synthesize 5-(3pyridyl)-2,2′-bithiophene(sensitizer) | FERMENTA BIOTECH LIMITED (IN) | 2025-08-26 | — | — | US | disclosed |
| US-12365927-B2 | Engineered ketoreductase polypeptides | CODEXIS, INC. (US) | 2025-07-22 | — | — | US | disclosed |
| CN-118726288-A | Recombinant ketoaldehyde reductase mutant and application thereof | 杭州微远生物科技有限公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-117089533-A | Recombinant carbonyl reductase, mutant, coding gene and application thereof | 浙江工业大学 | 2023-11-21 | — | — | CN | disclosed |
| CN-110229796-B | Ketoreductase mutant and application thereof in preparation of duloxetine chiral alcohol intermediate and analogue thereof | 安徽趣酶生物科技有限公司 | 2023-09-05 | — | — | CN | disclosed |
| EP-0766819-B1 | GAS SENSOR COMPRISING SEMICONDUCTING ORGANIC POLYMERS | AROMASCAN PLC (GB) | 1999-09-08 | — | — | EP | disclosed |
| EP-0454204-B1 | Method for the photochemical isomeration of organic compounds under the influence of a photosensitizer | DUPHAR INT RES (NL) | 1995-06-28 | — | — | EP | disclosed |
| US-5252191-A | Method for the photochemical isomerization of organic compounds under the influence of a photosensitizer | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1993-10-12 | — | — | US | disclosed |
| EP-0457559-A2 | Chiral synthesis of 1-aryl-3-aminopropan-1-ols | ELI LILLY AND COMPANY (US) | 1991-11-21 | — | — | EP | disclosed |
| EP-0454204-A2 | Method for the photochemical isomeration of organic compounds under the influence of a photosensitizer | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1991-10-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015362-A1 | Process for the preparation of optically active (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine | HTR3A, PNMT, TPH1 | ALDH1A1 143/4885LMNA 520/4885KMT2A 2173/4885 |
| US-20090123514-A1 | Electropolymerizable Monomers and Polymeric Coatings on Implantable Devices Prepared Therefrom | ITK, ICAM1, ITGAM | ALDH1A1 933/4885LMNA 2839/4885KMT2A 2872/4885 |
| US-20070281989-A1 | Process for preparing duloxetine and intermediates thereof | UGT1A4, CYP3A4, CYP4B1 | ALDH1A1 151/4885LMNA 885/4885KMT2A 2336/4885 |
| US-20090012315-A1 | Process for Pure Duloxetine Hydrochloride | OPRK1, OPRM1, OPRD1 | ALDH1A1 475/4885LMNA 2180/4885KMT2A 1298/4885 |
| US-12398126-B2 | Process to synthesize 5-(3pyridyl)-2,2′-bithiophene(sensitizer) | TPST2, TH, TDO2 | ALDH1A1 3314/4885LMNA 4509/4885KMT2A 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.