Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MDM4 | O15151 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
| ▸ | TUBB | P07437 | 1/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.31 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.31 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.31 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.31 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.31 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.31 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.31 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.31 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.31 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11978661 | 0.90 | NR3C1 (0.36) | TLR9TLR8TLR7NR3C1PDE10A | |
| SCHEMBL11979309 | 0.85 | MDM4 (0.46) | PDE10AMDM4MDM2TUBB4ATUBB | |
| SCHEMBL11978277 | 0.83 | TUBB4A (0.41) | PDE10AMDM4MDM2TUBB4ATUBB | |
| SCHEMBL15975192 | 0.80 | TUBB4A (0.35) | TLR9TLR8TLR7NR3C1TUBB4A | |
| SCHEMBL11977713 | 0.79 | TLR9 (0.34) | TLR9TLR8TLR7NR3C1PDE10A | |
| SCHEMBL11979314 | 0.78 | PDE10A (0.42) | PDE10AMDM4MDM2TUBB4ATUBB | |
| SCHEMBL3708601 | 0.77 | MTNR1A (0.39) | NR3C1MTNR1AMTNR1B | |
| SCHEMBL11978670 | 0.76 | DGAT1 (0.41) | TLR9TLR7NR3C1MTNR1AMTNR1B | |
| SCHEMBL11979317 | 0.75 | TUBB4A (0.38) | PDE10AMDM4MDM2TUBB4ATUBB | |
| SCHEMBL11978659 | 0.75 | MDM4 (0.46) | PDE10AMDM4MDM2TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |