Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11978656 | 0.82 | PDE10A (0.44) | PDE10AALDH1A1HPGDKMT2AF2 | |
| SCHEMBL11979705 | 0.78 | PDE10A (0.38) | PDE10APAX8ALDH1A1HPGDKMT2A | |
| SCHEMBL4568142 | 0.77 | PTGER1 (0.46) | KMT2AMEN1 | |
| SCHEMBL15975093 | 0.76 | PDE10A (0.42) | PDE10AALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL4568124 | 0.76 | MEN1 (0.44) | ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL11910116 | 0.75 | GRIK1 (0.50) | — | |
| SCHEMBL15975094 | 0.75 | CYP19A1 (0.47) | PDE10AALDH1A1KMT2AMEN1 | |
| SCHEMBL15975194 | 0.74 | PDE10A (0.40) | PDE10AALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL11978281 | 0.74 | TUBB4A (0.42) | PDE10AALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL15975129 | 0.73 | MTNR1A (0.41) | PDE10AALDH1A1HPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |