Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11979697 | 0.80 | TUBB4A (0.43) | PDE10AKMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL15975188 | 0.78 | PDE10A (0.42) | PDE10AMEN1KMT2APAX8ALDH1A1 | |
| SCHEMBL4568142 | 0.78 | PTGER1 (0.46) | MEN1KMT2A | |
| SCHEMBL4568124 | 0.76 | MEN1 (0.44) | MEN1KMT2AALDH1A1 | |
| SCHEMBL11979702 | 0.74 | PDE10A (0.39) | PDE10AMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL15975201 | 0.73 | PDE10A (0.38) | PDE10AMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL11979710 | 0.73 | ALDH1A1 (0.44) | PDE10AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL15975203 | 0.73 | PDE10A (0.38) | PDE10AMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL11979709 | 0.73 | CYP19A1 (0.48) | PDE10A | |
| SCHEMBL11978295 | 0.72 | PDE10A (0.37) | PDE10AMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| WO-2012102255-A1 | INDOLE DERIVATIVE AND PHARMACOLOGICALLY ACCEPTABLE SALT OF SAME | キッセイ薬品工業株式会社 (JP) | 2012-08-02 | — | — | WO | disclosed |