Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 10/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12196199 | 0.88 | EPHX1 (1.00) | EPHX1ALDH1A1CYP1A2NPC1RAB9A | |
| SCHEMBL12196033 | 0.86 | EPHX1 (1.00) | EPHX1ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL7375644 | 0.85 | HDAC1 (0.74) | EPHX1ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL14424481 | 0.85 | EPHX1 (0.97) | EPHX1ALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL30445477 | 0.83 | RAB9A (0.76) | EPHX1ALDH1A1KDM4EMEN1CYP1A2 | |
| SCHEMBL14424451 | 0.83 | EPHX1 (0.89) | EPHX1ALDH1A1KDM4EMEN1CYP1A2 | |
| SCHEMBL14423982 | 0.80 | EPHX1 (0.79) | EPHX1ALDH1A1KDM4EMEN1CYP1A2 | |
| SCHEMBL8248980 | 0.78 | HDAC1 (0.74) | KDM4ESMN1; SMN2HDAC1HDAC2HDAC8 | |
| SCHEMBL6875759 | 0.78 | EPHX1 (0.65) | EPHX1ALDH1A1KDM4EMEN1CYP1A2 | |
| SCHEMBL4902274 | 0.77 | EPHX1 (0.66) | EPHX1ALDH1A1KDM4EMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815951-B2 | Inhibitors of epoxide hydrolases for the treatment of inflammation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-08-26 | — | — | US | disclosed |