Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 6/20 | 0.89 |
| ▸ | RORC | P51449 | 5/20 | 0.89 |
| ▸ | OSBP2 | Q969R2 | 3/20 | 0.89 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.89 |
| ▸ | USP2 | O75604 | 1/20 | 0.89 |
| ▸ | LMNA | P02545 | 1/20 | 0.89 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.89 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.76 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.76 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.75 |
| ▸ | CRYAB | P02511 | 1/20 | 0.73 |
| ▸ | HMGCR | P04035 | 1/20 | 0.73 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.73 |
| ▸ | ITGAV | P06756 | 1/20 | 0.73 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.73 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.73 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.72 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.71 |
| ▸ | DHCR24 | Q15392 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL159924 | 1.00 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL192030 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL26086800 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL9458834 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL27579873 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL29094044 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL1965451 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL21879229 | 0.98 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL2160402 | 0.98 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL3792432 | 0.98 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110520131-A | The neurosteroid preparation of sustained release injectable | MARINUS PHARMACEUTICALS INC | 2019-11-29 | — | — | CN | claimed |
| CN-104856931-B | A kind of amphotericin B nano compound and preparation method thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2019-06-18 | — | — | CN | claimed |
| CN-109381707-A | A kind of azithromycin ion pair liposome eye drops and preparation method thereof | 沈阳药科大学 | 2019-02-26 | — | — | CN | claimed |
| CN-108135838-A | Injectable neurosteroid preparation comprising nanoparticle | 马瑞纳斯制药公司 | 2018-06-08 | — | — | CN | claimed |
| CN-104856931-A | Amphotericin B nano composite, and preparation method thereof | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY CHINA SHIJIAZHUANG CO LTD | 2015-08-26 | — | — | CN | claimed |
| CN-104292289-A | Galactose ligand and its application in liver targeting liposome | CHENG YI | 2015-01-21 | — | — | CN | claimed |
| CN-103622923-A | Drug delivery system for 16-dehydropregnenolone lipidosome for injection and preparation method of same | UNIV SHENYANG PHARMACEUTICAL | 2014-03-12 | — | — | CN | claimed |
| CN-102883753-A | Drug-releasing coatings for medical devices | LUTONIX INC | 2013-01-16 | — | — | CN | claimed |
| CN-119424667-A | Cholesterol derivative pharmaceutical composition and preparation method and application thereof | 沈阳药科大学 | 2025-02-14 | — | — | CN | disclosed |
| CN-115708809-A | Novel lipid nanoparticle for delivering nucleic acid drug and preparation method thereof | 李永 | 2023-02-24 | — | — | CN | disclosed |
| CN-114646702-B | Application of cholesterol sulfate detection reagent in preparation of sepsis auxiliary diagnosis, treatment effect monitoring and prognosis evaluation kit | 四川大学华西医院 | 2023-01-06 | — | — | CN | disclosed |
| CN-114646702-A | Application of cholesterol sulfate detection reagent in preparation of sepsis auxiliary diagnosis, treatment effect monitoring and prognosis evaluation kit | 四川大学华西医院 | 2022-06-21 | — | — | CN | disclosed |
| CN-105030555-B | Surfactant compositions and high oil content formulations containing the same | 赢创运营有限公司 | 2021-10-15 | — | — | CN | disclosed |
| CN-111100178-B | Preparation method of medicinal-grade cholesterol sodium sulfate | 石药集团中奇制药技术（石家庄）有限公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-102883753-A | Drug-releasing coatings for medical devices | LUTONIX INC | 2013-01-16 | — | — | CN | disclosed |
| CN-102231979-A | Liposome efficient delivery methods and compositions for gene silencing therapeutics | MDRNA INC | 2011-11-02 | — | — | CN | disclosed |
| CN-101939027-A | Lipopeptides for delivery of nucleic acids | MDRNA INC | 2011-01-05 | — | — | CN | disclosed |
| CN-101674853-A | Amino acid lipids and uses thereof | NASTECH PHARM CO | 2010-03-17 | — | — | CN | disclosed |
| CN-100496609-C | Stable liposome composition | AILISI MEDICINE TECH CO LTD (CN) | 2009-06-10 | — | — | CN | disclosed |
| CN-101002733-A | Stable elaioplast composition | AILISI MEDICINE TECH CO LTD SH (CN) | 2007-07-25 | — | — | CN | disclosed |