Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.54 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13826070 | 0.88 | POLB (0.67) | POLBHCRTR1HCRTR2SYKKDM4E | |
| SCHEMBL16002867 | 0.85 | SYK (0.47) | POLBHCRTR1HCRTR2SYKKDM4E | |
| SCHEMBL16002955 | 0.81 | GLA (0.66) | POLBHCRTR1HCRTR2SYKKDM4E | |
| SCHEMBL10293586 | 0.76 | MGLL (0.54) | POLBKDM4EHTR2BSMN1; SMN2L3MBTL1 | |
| SCHEMBL16002915 | 0.76 | ALDH1A1 (0.57) | POLBKDM4ETSHRALDH1A1LMNA | |
| SCHEMBL16002961 | 0.75 | RAB9A (0.67) | POLBKDM4EHTR2BALDH1A1TP53 | |
| SCHEMBL28292405 | 0.75 | HSD11B1 (0.55) | POLBHTR2BL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL16002990 | 0.75 | SMYD3 (0.52) | POLBSYKL3MBTL1KMT2ATDP1 | |
| SCHEMBL13825996 | 0.74 | POLB (0.48) | POLBHCRTR1HCRTR2SYKKDM4E | |
| SCHEMBL16002986 | 0.73 | ALDH1A1 (0.47) | POLBSYKHTR2BSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9145391-B2 | Bipyridylaminopyridines as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-09-29 | — | — | US | disclosed |
| US-20140249130-A1 | BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME LLC | 2014-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249130-A1 | BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS | SYK, BTK, LCK | POLB 1761/4885HCRTR1 4159/4885HCRTR2 4064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.