SCHEMBL1600375

SCHEMBL1600375

COC(C)(c1ccc(C(F)(F)F)cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1)C1CCCCC1

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CETP P11597 19/20 0.42
TACR1 P25103 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1600911 1.00 CETP (0.42) CETPTACR1
SCHEMBL1601549 1.00 CETP (0.42) CETPTACR1
SCHEMBL1600786 1.00 CETP (0.42) CETPTACR1
SCHEMBL1601267 0.99 CETP (0.42) CETPTACR1
SCHEMBL1600245 0.99 CETP (0.42) CETPTACR1
SCHEMBL12707795 0.99 CETP (0.42) CETPTACR1
SCHEMBL1600687 0.97 CETP (0.42) CETPTACR1
SCHEMBL1601335 0.89 CETP (0.37) CETP
SCHEMBL1599672 0.88 CETP (0.41) CETP
SCHEMBL1600305 0.88 CETP (0.42) CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8703204-B2 Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer BEND RESEARCH, INC. (US) 2014-04-22 US claimed
US-7919506-B2 Dibenzyl amine compounds and derivatives PFIZER INC. (US) 2011-04-05 US claimed
US-20100129447-A1 NANOPARTICLES COMPRISING A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR AND ANON-IONIZABLE POLYMER BEND RESEARCH, INC. 2010-05-27 US claimed
US-20100062073-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING NANOPARTICLES COMPRISING ENTERIC POLYMERS CASEIN BEND RESEARCH, INC. 2010-03-11 US claimed
WO-2008135855-A2 NANOPARTICLES COMPRISING A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR AND A NONIONIZABLE POLYMER PFIZER PRODUCTS INC. (US) 2008-11-13 WO claimed
WO-2008065502-A1 PHARMACEUTICAL COMPOSITIONS BASED ON A) NANOPARTICLES COMPRISING ENTERIC POLYMERS AND B) CASEIN PFIZER PRODUCTS INC. (US) 2008-06-05 WO claimed
US-20070213371-A1 Dibenzyl Amine Compounds and Derivatives PFIZER INC 2007-09-13 US claimed
US-9724362-B2 Pharmaceutical compositions comprising nanoparticles and a resuspending material BEND RESEARCH, INC. (US) 2017-08-08 US disclosed
US-9545384-B2 Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate BEND RESEARCH, INC. (US) 2017-01-17 US disclosed
EP-2231169-B1 PHARMACEUTICAL COMPOSITIONS COMPRISING NANOPARTICLES AND A RESUSPENDING MATERIAL BEND RES INC (US) 2016-05-04 EP disclosed
EP-2162120-B1 NANOPARTICLES COMPRISING A NON-IONIZABLE CELLULOSIC POLYMER AND AN AMPHIPHILIC NON-IONIZABLE BLOCK COPOLYMER BEND RES INC (US) 2016-05-04 EP disclosed
US-9233078-B2 Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer BEND RESEARCH, INC. (US) 2016-01-12 US disclosed
US-8974827-B2 Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer BEND RESEARCH, INC. (US) 2015-03-10 US disclosed
WO-2008135828-A2 NANOPARTICLES COMPRISING A DRUG, ETHYLCELLULOSE, AND A BILE SALT PFIZER PRODUCTS INC. (US) 2008-11-13 WO disclosed
WO-2008065502-A1 PHARMACEUTICAL COMPOSITIONS BASED ON A) NANOPARTICLES COMPRISING ENTERIC POLYMERS AND B) CASEIN PFIZER PRODUCTS INC. (US) 2008-06-05 WO disclosed
WO-2007105050-A1 DIBENZYL AMINE COMPOUNDS AND DERIVATIVES PFIZER PRODUCTS INC. (US) 2007-09-20 WO disclosed
WO-2007105050-A1 DIBENZYL AMINE COMPOUNDS AND DERIVATIVES PFIZER PRODUCTS INC. (US) 2007-09-20 WO disclosed
US-20070213371-A1 Dibenzyl Amine Compounds and Derivatives PFIZER INC 2007-09-13 US disclosed
US-20070213371-A1 Dibenzyl Amine Compounds and Derivatives PFIZER INC 2007-09-13 US disclosed
US-20070213371-A1 Dibenzyl Amine Compounds and Derivatives PFIZER INC 2007-09-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100129447-A1 NANOPARTICLES COMPRISING A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR AND ANON-IONIZABLE POLYMER CETP, CHLSN, PCTP CETP 1/4885TACR1 3164/4885
US-20100062073-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING NANOPARTICLES COMPRISING ENTERIC POLYMERS CASEIN CSNK1G3, CSNK2A3, CSNK1A1 CETP 54/4885TACR1 3473/4885
US-20070213371-A1 Dibenzyl Amine Compounds and Derivatives APOB, LDLR, CETP CETP 3/4885TACR1 2334/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.