Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 14/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004004 | 0.88 | GPR142 (0.49) | GPR142LMNAALDH1A1FAAH | |
| SCHEMBL16004005 | 0.88 | GPR142 (0.48) | GPR142LMNAALDH1A1 | |
| SCHEMBL16004321 | 0.87 | GPR142 (0.54) | GPR142LMNAALDH1A1 | |
| SCHEMBL16004001 | 0.85 | GPR142 (0.49) | GPR142LMNAALDH1A1 | |
| SCHEMBL16003996 | 0.82 | GPR142 (0.60) | GPR142LMNAALDH1A1FAAHMAPT | |
| SCHEMBL16004324 | 0.82 | ALDH1A1 (0.44) | GPR142LMNAALDH1A1MAPT | |
| SCHEMBL16004158 | 0.81 | RAB9A (0.48) | GPR142LMNAALDH1A1MAPT | |
| SCHEMBL16004310 | 0.79 | GPR142 (0.53) | GPR142MAPT | |
| SCHEMBL16003998 | 0.77 | GPR142 (0.51) | GPR142ALDH1A1FAAH | |
| SCHEMBL16004312 | 0.77 | NPC1 (0.46) | GPR142LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |