Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GPR142 | Q7Z601 | 12/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004310 | 0.91 | GPR142 (0.53) | RAB9ANPC1GPR142MAPTMEN1 | |
| SCHEMBL16004312 | 0.89 | NPC1 (0.46) | RAB9ANPC1GPR142MAPTMEN1 | |
| SCHEMBL16003998 | 0.89 | GPR142 (0.51) | RAB9AGPR142ALDH1A1SMN1; SMN2 | |
| SCHEMBL16004106 | 0.86 | GPR142 (0.51) | RAB9ANPC1GPR142MAPTALDH1A1 | |
| SCHEMBL16004321 | 0.84 | GPR142 (0.54) | RAB9ANPC1GPR142ALDH1A1LMNA | |
| SCHEMBL16004001 | 0.82 | GPR142 (0.49) | RAB9ANPC1GPR142ALDH1A1LMNA | |
| SCHEMBL16004004 | 0.81 | GPR142 (0.49) | RAB9ANPC1GPR142MEN1KMT2A | |
| SCHEMBL16004005 | 0.81 | GPR142 (0.48) | RAB9ANPC1GPR142ALDH1A1LMNA | |
| SCHEMBL16004156 | 0.81 | GPR142 (0.57) | RAB9AGPR142MAPTALDH1A1 | |
| SCHEMBL16004002 | 0.81 | GPR142 (0.47) | GPR142MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |