Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 12/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16003998 | 0.91 | GPR142 (0.51) | GPR142CREBBPALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL16004158 | 0.86 | RAB9A (0.48) | GPR142MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL16004088 | 0.85 | GPR142 (0.57) | GPR142TAS1R3TAS1R1TAS1R2CYP2D6 | |
| SCHEMBL16004096 | 0.84 | MAPT (0.55) | GPR142CREBBPMAPTNPC1RAB9A | |
| SCHEMBL16004070 | 0.84 | GPR142 (0.49) | GPR142HTTCREBBPMAPTTAS1R3 | |
| SCHEMBL16003987 | 0.83 | CREBBP (0.44) | GPR142CREBBPMAPTSMN1; SMN2NPC1 | |
| SCHEMBL16004092 | 0.83 | GPR142 (0.53) | GPR142CREBBPNAMPTRIPK1 | |
| SCHEMBL16004156 | 0.82 | GPR142 (0.57) | GPR142MAPTALDH1A1RAB9AFAAH | |
| SCHEMBL16004157 | 0.82 | GPR142 (0.58) | GPR142NAMPTFAAH | |
| SCHEMBL16004314 | 0.81 | GPR142 (0.56) | GPR142SMN1; SMN2NPC1RAB9ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |