Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 3/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | MGAT3 | Q09327 | 2/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004302 | 0.91 | ALDH1A1 (0.51) | GPR142SMN1; SMN2MAPTRIPK1L3MBTL1 | |
| SCHEMBL16004149 | 0.88 | GPR142 (0.42) | GPR142ABCB1ABCC1SMN1; SMN2MAPT | |
| SCHEMBL16004153 | 0.88 | GPR142 (0.42) | GPR142ABCB1ABCC1SMN1; SMN2MAPT | |
| SCHEMBL16004165 | 0.88 | GPR142 (0.42) | GPR142ABCB1ABCC1SMN1; SMN2MAPT | |
| SCHEMBL16004148 | 0.88 | GPR142 (0.46) | GPR142ABCB1ABCC1SMN1; SMN2MAPT | |
| SCHEMBL16004248 | 0.87 | ABCB1 (0.50) | GPR142ABCB1ABCC1SMN1; SMN2MAPT | |
| SCHEMBL16004253 | 0.87 | SMN1; SMN2 (0.54) | GPR142ABCB1ABCC1SMN1; SMN2MAPT | |
| SCHEMBL16004134 | 0.86 | ABCB1 (0.48) | GPR142ABCB1ABCC1SMN1; SMN2MAPT | |
| SCHEMBL16004091 | 0.86 | ALDH1A1 (0.48) | GPR142ABCB1ABCC1SMN1; SMN2MAPT | |
| SCHEMBL16004138 | 0.85 | SIGMAR1 (0.48) | GPR142MAPTKMT2AMGAT3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |