Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004143 | 0.84 | LMNA (0.43) | LMNAGAAKCNA5HTTSMN1; SMN2 | |
| SCHEMBL16004095 | 0.84 | LMNA (0.43) | LMNAGAAKCNA5HTTSMN1; SMN2 | |
| SCHEMBL16004103 | 0.83 | LMNA (0.44) | LMNAGAACHRM2CHRM3HTT | |
| SCHEMBL16003983 | 0.81 | GAA (0.43) | LMNAGAACHRM2CHRM3HTT | |
| SCHEMBL16003974 | 0.81 | HRH3 (0.52) | LMNAGAAKCNA5KMT2A | |
| SCHEMBL16004296 | 0.81 | MEN1 (0.42) | SMN1; SMN2ALDH1A1MEN1KMT2AGPR142 | |
| SCHEMBL16004335 | 0.79 | MEN1 (0.43) | GAASMN1; SMN2ALDH1A1POLBMEN1 | |
| SCHEMBL16003993 | 0.78 | GAA (0.51) | LMNAGAAHTTALDH1A1MEN1 | |
| SCHEMBL16004056 | 0.77 | LMNA (0.47) | LMNAGAACHRM2CHRM3HTT | |
| SCHEMBL16004319 | 0.76 | GPR142 (0.60) | SMN1; SMN2ALDH1A1POLBTP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |