Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004095 | 0.85 | LMNA (0.43) | LMNARIPK1GAAKDM4EALDH1A1 | |
| SCHEMBL16004103 | 0.84 | LMNA (0.44) | LMNAGAAALDH1A1CYP2C9HTT | |
| SCHEMBL16004140 | 0.84 | LMNA (0.44) | LMNAGPR142RIPK1GAAALDH1A1 | |
| SCHEMBL16003974 | 0.83 | HRH3 (0.52) | LMNAGAAKCNA5 | |
| SCHEMBL16003983 | 0.83 | GAA (0.43) | LMNARIPK1GAAALDH1A1CYP2C9 | |
| SCHEMBL16003973 | 0.83 | TSHR (0.46) | GPR142RIPK1KDM4EALDH1A1HTT | |
| SCHEMBL16004139 | 0.80 | ALDH1A1 (0.53) | LMNAGPR142RIPK1KDM4EALDH1A1 | |
| SCHEMBL16003982 | 0.80 | ALDH1A1 (0.45) | GPR142RIPK1KDM4EALDH1A1HTT | |
| SCHEMBL16004295 | 0.80 | RIPK1 (0.44) | GPR142RIPK1KDM4EALDH1A1HTT | |
| SCHEMBL16004094 | 0.80 | GPR142 (0.64) | GPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |