Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 15/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004279 | 0.91 | ALDH1A1 (0.46) | GPR142RYR2 | |
| SCHEMBL16004075 | 0.90 | ABCC1 (0.43) | GPR142CREBBPFAAHRYR2CYP2D6 | |
| SCHEMBL16004276 | 0.87 | CREBBP (0.40) | GPR142CREBBPFAAHRYR2CYP2D6 | |
| SCHEMBL16004289 | 0.85 | ABCC1 (0.41) | GPR142CREBBPFAAHRYR2CYP2D6 | |
| SCHEMBL16004278 | 0.84 | GPR142 (0.59) | GPR142FAAH | |
| SCHEMBL16004285 | 0.82 | CREBBP (0.54) | CREBBP | |
| SCHEMBL16004287 | 0.82 | KMT2A (0.46) | GPR142RYR2 | |
| SCHEMBL16004070 | 0.81 | GPR142 (0.49) | GPR142CREBBPFAAHCYP2D6 | |
| SCHEMBL16004281 | 0.81 | CREBBP (0.39) | GPR142CREBBPRYR2CYP2D6 | |
| SCHEMBL16004071 | 0.80 | GPR142 (0.60) | GPR142FAAHCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |