Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004290 | 0.90 | CREBBP (0.47) | GPR142CREBBP | |
| SCHEMBL16004244 | 0.85 | GPR142 (0.37) | GPR142ALDH1A1SMN1; SMN2RIPK1CREBBP | |
| SCHEMBL16004117 | 0.85 | KDM4E (0.43) | GPR142ALDH1A1SMN1; SMN2RIPK1FAAH | |
| SCHEMBL16004421 | 0.81 | GPR142 (0.43) | GPR142ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL16004291 | 0.79 | MAPT (0.47) | GPR142RIPK1CREBBPNAMPT | |
| SCHEMBL16004068 | 0.76 | MAPT (0.49) | GPR142ALDH1A1CREBBPNAMPT | |
| SCHEMBL16003971 | 0.75 | MAPT (0.35) | ALDH1A1MGLLNPSR1 | |
| SCHEMBL16003966 | 0.75 | MEN1 (0.36) | ALDH1A1MGLLNPSR1 | |
| SCHEMBL16004278 | 0.75 | GPR142 (0.59) | GPR142SMN1; SMN2FAAHNAMPT | |
| SCHEMBL16003967 | 0.75 | LMNA (0.40) | ALDH1A1RIPK1MGLLNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |