Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12178006 | 0.90 | NAMPT (0.44) | LTA4HCHEK2BCHEACHEKCNH2 | |
| SCHEMBL14718387 | 0.84 | QDPR (0.36) | CHEK2ALDH1A1SMN1; SMN2 | |
| SCHEMBL14718555 | 0.83 | CNR1 (0.37) | KCNH2ALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL2585277 | 0.83 | GPR119 (0.57) | LTA4HCHEK2BCHEACHEDRD4 | |
| SCHEMBL2594050 | 0.82 | CHEK2 (0.42) | LTA4HCHEK2BCHEACHEKCNH2 | |
| SCHEMBL14728992 | 0.82 | GPR119 (0.47) | LTA4HCHEK2BCHEACHEKCNH2 | |
| SCHEMBL14731949 | 0.81 | BCHE (0.38) | LTA4HCHEK2BCHEACHEKCNH2 | |
| SCHEMBL2594174 | 0.81 | KDM4E (0.35) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2588067 | 0.80 | GPR119 (0.43) | — | |
| SCHEMBL2585694 | 0.80 | LTA4H (0.42) | LTA4HCHEK2BCHEACHEKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566860-B1 | BICYCLIC HETEROARYL COMPOUNDS AS GPR119 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2014-09-10 | — | — | EP | disclosed |