Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594050 | 0.82 | CHEK2 (0.42) | LTA4HCHEK2ROCK1ROCK2CCR2 | |
| SCHEMBL16005681 | 0.80 | LTA4H (0.45) | LTA4HCHEK2ROCK1ROCK2CCR2 | |
| SCHEMBL2592883 | 0.79 | LTA4H (0.48) | LTA4HCHEK2ROCK1ROCK2CCR2 | |
| SCHEMBL12178006 | 0.77 | NAMPT (0.44) | LTA4HCHEK2BCHEACHEKCNH2 | |
| SCHEMBL2585277 | 0.76 | GPR119 (0.57) | LTA4HCHEK2BCHEACHEDRD2 | |
| SCHEMBL14731949 | 0.74 | BCHE (0.38) | LTA4HCHEK2ROCK1ROCK2CCR2 | |
| SCHEMBL14728992 | 0.73 | GPR119 (0.47) | LTA4HCHEK2BCHEACHEKCNH2 | |
| SCHEMBL8088919 | 0.64 | HRH3 (0.52) | ROCK1ROCK2CCR2ACHEKCNH2 | |
| SCHEMBL4855546 | 0.63 | HRH3 (0.74) | ROCK1ROCK2CCR2ACHEDRD2 | |
| SCHEMBL14718387 | 0.62 | QDPR (0.36) | CHEK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566860-A1 | BICYCLIC HETEROARYL COMPOUNDS AS GPR119 MODULATORS | Bristol-Myers Squibb Company (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140160-A1 | BICYCLIC HETEROARYL COMPOUNDS AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-11-10 | — | — | WO | disclosed |