Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL11801333 | 1.00 | APP (0.37) | APPEPHX2PTGS1PDE4ALMNA | |
| Potassium Ion SCHEMBL16010564 | 1.00 | APP (0.37) | APPEPHX2PTGS1PDE4ALMNA | |
| SCHEMBL10490320 | 0.98 | APP (0.35) | APPEPHX2 | |
| SCHEMBL15901662 | 0.98 | APP (0.35) | APPEPHX2 | |
| Potassium Ion SCHEMBL444305 | 0.98 | APP (0.38) | APPEPHX2PTGS1PDE4ALMNA | |
| SCHEMBL16010310 | 0.96 | APP (0.37) | APPPTGS1PDE4ALMNASLC6A6 | |
| Lithium Ion SCHEMBL10598662 | 0.96 | APP (0.37) | APPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL219270 | 0.96 | APP (0.37) | APPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL17476621 | 0.96 | APP (0.37) | APPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL11973834 | 0.96 | APP (0.37) | APPPTGS1PDE4ALMNASLC6A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273222-B2 | Composition and film comprising same | MITSUI CHEMICALS, INC. (JP) | 2016-03-01 | — | — | US | disclosed |
| US-20160046827-A1 | FILM COMPRISING COPOLYMER OR COMPOSITION | MITSUI CHEMICALS, INC. (JP) | 2016-02-18 | — | — | US | disclosed |
| US-20160032036-A1 | COPOLYMER AND HYDROPHILIC MATERIAL COMPOSED OF THE SAME | MITSUI CHEMICALS, INC. (JP) | 2016-02-04 | — | — | US | disclosed |
| US-20140256870-A1 | COMPOSITION AND FILM COMPRISING SAME | MITSUI CHEMICALS, INC. (JP) | 2014-09-11 | — | — | US | disclosed |