SCHEMBL16012189

SCHEMBL16012189

C=COCCCCOC(COC(=O)CCCCCCC)COC(=O)CCCCCCC

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.56
▸ LMNA P02545 1/20 0.56
▸ PRKCA P17252 4/20 0.52
▸ PRKCE Q02156 2/20 0.52
▸ PRKCQ Q04759 2/20 0.52
▸ PRKCD Q05655 2/20 0.52
▸ TSHR P16473 1/20 0.50
▸ MAPT P10636 1/20 0.50
▸ DGKA P23743 1/20 0.49
▸ ENPP2 Q13822 4/20 0.48
▸ KDM4E B2RXH2 1/20 0.48
▸ DUSP3 P51452 1/20 0.48
▸ MEN1 O00255 1/20 0.48
▸ KMT2A Q03164 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3937050 0.89 LMNA (0.70) ALDH1A1LMNAPRKCAPRKCEPRKCQ
SCHEMBL2152312 0.84 LMNA (0.64) ALDH1A1LMNAPRKCAPRKCEPRKCQ
SCHEMBL2152561 0.84 LMNA (0.64) ALDH1A1LMNAPRKCAPRKCEPRKCQ
SCHEMBL2152572 0.84 LMNA (0.64) ALDH1A1LMNAPRKCAPRKCEPRKCQ
SCHEMBL6018541 0.84 LMNA (0.64) ALDH1A1LMNAPRKCAPRKCEPRKCQ
SCHEMBL2152798 0.84 LMNA (0.64) ALDH1A1LMNAPRKCAPRKCEPRKCQ
SCHEMBL18106999 0.84 LMNA (0.64) ALDH1A1LMNAPRKCAPRKCEPRKCQ
SCHEMBL2152823 0.84 LMNA (0.64) ALDH1A1LMNAPRKCAPRKCEPRKCQ
SCHEMBL2152579 0.84 LMNA (0.64) ALDH1A1LMNAPRKCAPRKCEPRKCQ
SCHEMBL218151 0.84 DGKA (0.65) ALDH1A1LMNATSHRMAPTDGKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3608308-B1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS NOVARTIS AG (CH) 2021-07-21 — — EP disclosed
US-10792361-B2 Lipids and lipid compositions for the delivery of active agents NOVARTIS AG (CH) 2020-10-06 — — US disclosed
EP-3608308-A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS Novartis AG (CH) 2020-02-12 — — EP disclosed
EP-2964608-B1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS NOVARTIS AG (CH) 2019-08-28 — — EP disclosed
US-20180369386-A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. 2018-12-27 — — US disclosed
US-10124065-B2 Lipids and lipid compositions for the delivery of active agents NOVARTIS AG (CH) 2018-11-13 — — US disclosed
US-20160106842-A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. 2016-04-21 — — US disclosed
US-20160106842-A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. 2016-04-21 — — US disclosed
US-20160106842-A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. 2016-04-21 — — US disclosed
EP-2964608-A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS Novartis AG (CH) 2016-01-13 — — EP disclosed
WO-2014136086-A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS NOVARTIS AG (CH) 2014-09-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10124065-B2 Lipids and lipid compositions for the delivery of active agents LIPA, LPAR1, LPAR4 ALDH1A1 2488/4885LMNA 679/4885PRKCA 2977/4885
US-20180369386-A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS LIPA, LPAR1, LPAR4 ALDH1A1 2488/4885LMNA 679/4885PRKCA 2977/4885
US-20160106842-A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS LIPA, LPAR1, LPAR4 ALDH1A1 2488/4885LMNA 679/4885PRKCA 2977/4885
US-10792361-B2 Lipids and lipid compositions for the delivery of active agents LIPA, LPAR1, LPAR4 ALDH1A1 2488/4885LMNA 679/4885PRKCA 2977/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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