Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | FASN | P49327 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16012351 | 0.88 | PTPN1 (0.41) | MAPTTDP1 | |
| SCHEMBL16012352 | 0.88 | PTPN1 (0.41) | MAPTTDP1 | |
| SCHEMBL17351911 | 0.88 | PTPN1 (0.41) | MAPTTDP1 | |
| SCHEMBL17356820 | 0.71 | PTPN1 (0.38) | ADORA2BSMN1; SMN2MAPTTDP1 | |
| SCHEMBL20669542 | 0.67 | TSHR (0.40) | TSHRMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23655520 | 0.63 | TSHR (0.37) | TSHRMEN1KMT2A | |
| SCHEMBL17356818 | 0.61 | PTPN1 (0.53) | MAPTTDP1 | |
| SCHEMBL17356821 | 0.61 | PTPN1 (0.53) | MAPTTDP1 | |
| SCHEMBL3336466 | 0.59 | — | — | |
| SCHEMBL9718044 | 0.58 | BUB1 (0.45) | TSHRMEN1KMT2AHSD17B10ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2965758-B1 | OSTEOPONTIN PRODUCTION INHIBITOR COMPRISING DICTYOPYRONE DERIVATIVE OR DIHYDRODICTYOPYRONE DERIVATIVE AS ACTIVE INGREDIENT | UNIV TOHOKU (JP) | 2018-01-03 | — | — | EP | disclosed |
| CN-105209038-B | Osteopontin with dictyostelium discoideum pyrone derivative or dihydro dictyostelium discoideum pyrone derivative as active ingredient produces inhibitor | 国立大学法人东北大学 | 2017-06-09 | — | — | CN | disclosed |
| US-9463188-B2 | Osteopontin production inhibitor containing dictyopyrone derivative or dihydrodictyopyrone derivative as active ingredient | TOHOKU UNIVERSITY (JP) | 2016-10-11 | — | — | US | disclosed |
| EP-2965758-A1 | OSTEOPONTIN PRODUCTION INHIBITOR COMPRISING DICTYOPYRONE DERIVATIVE OR DIHYDRODICTYOPYRONE DERIVATIVE AS ACTIVE INGREDIENT | Tohoku University (JP) | 2016-01-13 | — | — | EP | disclosed |
| CN-105209038-A | Osteopontin production inhibitor comprising dictyopyrone derivative or dihydrodictyopyrone derivative as active ingredient | UNIV TOHOKU NAT UNIV CORP | 2015-12-30 | — | — | CN | disclosed |
| US-20150366851-A1 | OSTEOPONTIN PRODUCTION INHIBITOR CONTAINING DICTYOPYRONE DERIVATIVE OR DIHYDRODICTYOPYRONE DERIVATIVE AS ACTIVE INGREDIENT | TOHOKU UNIVERSITY (JP) | 2015-12-24 | — | — | US | disclosed |
| WO-2014136161-A1 | OSTEOPONTIN PRODUCTION INHIBITOR COMPRISING DICTYOPYRONE DERIVATIVE OR DIHYDRODICTYOPYRONE DERIVATIVE AS ACTIVE INGREDIENT | 国立大学法人東北大学 (JP) | 2014-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150366851-A1 | OSTEOPONTIN PRODUCTION INHIBITOR CONTAINING DICTYOPYRONE DERIVATIVE OR DIHYDRODICTYOPYRONE DERIVATIVE AS ACTIVE INGREDIENT | SPPL2B, DPYSL3, DIAPH1 | ADORA2B 4575/4885TSHR 4489/4885KDM4E 4536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.