Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | KEAP1 | Q14145 | 14/20 | 0.63 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14933926 | 0.87 | KEAP1 (0.67) | ALDH1A1NPSR1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL18066433 | 0.81 | KEAP1 (0.73) | ALDH1A1NPSR1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL16017653 | 0.80 | KEAP1 (0.80) | ALDH1A1NPSR1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL16017652 | 0.80 | KEAP1 (0.80) | ALDH1A1NPSR1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL16017648 | 0.80 | KEAP1 (0.80) | ALDH1A1NPSR1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL23815777 | 0.80 | KEAP1 (0.80) | ALDH1A1NPSR1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL23682781 | 0.80 | KEAP1 (0.80) | ALDH1A1NPSR1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL16017682 | 0.80 | KEAP1 (0.80) | ALDH1A1NPSR1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL16017683 | 0.80 | KEAP1 (0.80) | ALDH1A1NPSR1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL16017684 | 0.80 | KEAP1 (0.80) | ALDH1A1NPSR1SMN1; SMN2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148408-A1 | DIRECT INHIBITORS OF KEAP1-NRF2 INTERACTION AS ANTIOXIDANT INFLAMMATION MODULATORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2018-05-31 | — | — | US | disclosed |
| US-20140256767-A1 | DIRECT INHIBITORS OF KEAP1-NRF2 INTERACTION AS ANTIOXIDANT INFLAMMATION MODULATORS | THE BROAD INSTITUTE, INC. (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148408-A1 | DIRECT INHIBITORS OF KEAP1-NRF2 INTERACTION AS ANTIOXIDANT INFLAMMATION MODULATORS | KEAP1, NFE2L2, HMOX1 | ALDH1A1 1021/4885NPSR1 3759/4885SMN1; SMN2 2916/4885 |
| US-20140256767-A1 | DIRECT INHIBITORS OF KEAP1-NRF2 INTERACTION AS ANTIOXIDANT INFLAMMATION MODULATORS | KEAP1, NFE2L2, HMOX1 | ALDH1A1 1021/4885NPSR1 3759/4885SMN1; SMN2 2916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.