Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | DGKA | P23743 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16017894 | 1.00 | ADRA2A (0.43) | ADRA2AADRA1AMAPTBLMDGKA | |
| SCHEMBL16017769 | 1.00 | ADRA2A (0.43) | ADRA2AADRA1AMAPTBLMDGKA | |
| SCHEMBL16017794 | 0.91 | ADRA2A (0.37) | ADRA2AADRA1AMAPTBLMDGKA | |
| SCHEMBL26304677 | 0.91 | ADRA2A (0.37) | ADRA2AADRA1AMAPTBLMDGKA | |
| SCHEMBL16019101 | 0.89 | ADRA2A (0.36) | ADRA2AADRA1AMAPTBLMDGKA | |
| SCHEMBL16019104 | 0.89 | ADRA2A (0.36) | ADRA2AADRA1AMAPTBLMDGKA | |
| SCHEMBL16017788 | 0.89 | ADRA2A (0.36) | ADRA2AADRA1AMAPTBLMDGKA | |
| SCHEMBL16017781 | 0.89 | ADRA2A (0.36) | ADRA2AADRA1AMAPTBLMDGKA | |
| SCHEMBL14665729 | 0.88 | DGKA (0.47) | ADRA2AADRA1AMAPTBLMDGKA | |
| SCHEMBL12938433 | 0.88 | DGKA (0.52) | ADRA2AADRA1AMAPTBLMDGKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256694-A1 | STEROID ANTIBIOTIC CONJUGATES | ALLERGAN, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256658-A1 | Antibiotic Conjugates | ALLERGAN, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256666-A1 | ANTIBIOTIC CONJUGATES WITH NONSTEROIDAL ANTI-INFLAMMATORY DRUGS | ALLERGAN, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256660-A1 | ANTIBIOTIC CONJUGATES LINKED WITH STEROID DRUGS | ALLERGAN, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256696-A1 | Steroid conjugates | ALLERGAN, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256651-A1 | Cyclosporine A steroid conjugates | ALLERGAN, INC. (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256666-A1 | ANTIBIOTIC CONJUGATES WITH NONSTEROIDAL ANTI-INFLAMMATORY DRUGS | MMP17, NAALAD2, DNPEP | ADRA2A 4765/4885ADRA1A 4558/4885MAPT 3276/4885 |
| US-20140256694-A1 | STEROID ANTIBIOTIC CONJUGATES | CYP17A1, CYP21A2, HSD17B1 | ADRA2A 4204/4885ADRA1A 3020/4885MAPT 3434/4885 |
| US-20140256660-A1 | ANTIBIOTIC CONJUGATES LINKED WITH STEROID DRUGS | CYP21A2, CYP17A1, CYP46A1 | ADRA2A 4577/4885ADRA1A 3774/4885MAPT 3692/4885 |
| US-20140256658-A1 | Antibiotic Conjugates | NAALAD2, DNPEP, ENGASE | ADRA2A 4665/4885ADRA1A 4225/4885MAPT 2636/4885 |
| US-20140256696-A1 | Steroid conjugates | CYP21A2, CYP17A1, HSD17B2 | ADRA2A 2246/4885ADRA1A 1342/4885MAPT 2769/4885 |
| US-20140256651-A1 | Cyclosporine A steroid conjugates | CYP21A2, CHP1, CYP51A1 | ADRA2A 2407/4885ADRA1A 1692/4885MAPT 4019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.