Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 4/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | LGMN | Q99538 | 1/20 | 0.49 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911977 | 0.86 | PRKDC (0.58) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1911932 | 0.83 | MAPT (0.69) | PRKDCMAPTPKMGAAALDH1A1 | |
| SCHEMBL11791151 | 0.83 | PRKDC (0.65) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1599743 | 0.83 | ALDH1A1 (0.49) | PRKDCMAPTPKMGAAALDH1A1 | |
| SCHEMBL1599707 | 0.81 | HPGD (0.50) | PRKDCMAPTPKMGAAALDH1A1 | |
| SCHEMBL1599368 | 0.80 | SIRT6 (0.58) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL8263576 | 0.80 | MAPT (0.62) | PRKDCMAPTGAAALDH1A1KDM4E | |
| SCHEMBL13182855 | 0.80 | LGMN (0.64) | PRKDCMAPTPKMGAAALDH1A1 | |
| SCHEMBL1600023 | 0.79 | ADRB1 (0.71) | ALDH1A1KDM4EHTTTP53CYP1A2 | |
| SCHEMBL24885846 | 0.79 | MAPT (0.56) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1870084-B1 | Composition for dyeing keratin fibres comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 6-chloro 2-methyl 5-aminophenol and a substituted meta-aminophenol | ORÉAL L (FR) | 2015-07-22 | — | — | EP | claimed |
| EP-1870085-B1 | Composition for dyeing keratinous fibres comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, para-phenylenediamine or para-toluenediamine and a substituted meta-aminophenol | ORÉAL L (FR) | 2015-07-22 | — | — | EP | claimed |
| US-7651536-B2 | Composition for dyeing of keratin fibers, comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, at least one oxidation base chosen from para-phenylenediamine and para-tolylenediamine, and a substituted meta-aminophenol | L'OREAL S.A. (FR) | 2010-01-26 | — | — | US | claimed |
| US-7651537-B2 | Composition for dyeing keratin fibers, comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 6-chloro-2-methyl-5-aminophenol and a substituted meta-aminophenol | L'OREAL S.A. (FR) | 2010-01-26 | — | — | US | claimed |
| US-20080016627-A1 | Composition for dyeing of keratin fibers, comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, at least one oxidation base chosen from para-phenylenediamine and para-tolylenediamine, and a substituted meta-aminophenol | L'OREAL S.A. (FR) | 2008-01-24 | — | — | US | claimed |
| US-20080016628-A1 | Composition for dyeing keratin fibers, comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 6-chloro-2-methyl-5-aminophenol and a substituted meta-aminophenol | L'OREAL S.A. (FR) | 2008-01-24 | — | — | US | claimed |
| EP-1870085-A2 | Composition for dyeing keratinous fibres comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, para-phenylenediamine or para-toluenediamine and a substituted meta-aminophenol | L'Oréal (FR) | 2007-12-26 | — | — | EP | claimed |
| EP-1870084-A2 | Composition for dyeing keratin fibres comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 6-chloro 2-methyl 5-aminophenol and a substituted meta-aminophenol | L'Oréal (FR) | 2007-12-26 | — | — | EP | claimed |
| EP-1870084-B1 | Composition for dyeing keratin fibres comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 6-chloro 2-methyl 5-aminophenol and a substituted meta-aminophenol | ORÉAL L (FR) | 2015-07-22 | — | — | EP | disclosed |
| EP-1870085-B1 | Composition for dyeing keratinous fibres comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, para-phenylenediamine or para-toluenediamine and a substituted meta-aminophenol | ORÉAL L (FR) | 2015-07-22 | — | — | EP | disclosed |
| CN-101181188-B | Method for staining cutin fiber and staining reagent box or device | OREAL | 2013-04-03 | — | — | CN | disclosed |
| EP-2275413-B1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |
| EP-1927377-B1 | Dye composition of acidic pH comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, a para- phenylenediamine, a meta-aminophenol and an oxidizing agent | OREAL (FR) | 2012-12-26 | — | — | EP | disclosed |
| CN-101091691-B | Keratin fibre dyeing composition containing 2, 3-diamino-6, 7-dihydro-1H, 5H-pyrazolo [1,2-a ] pyrazol-1-one, 6-chloro-2-methyl-5-aminophenol and substituted meta-aminophenol | OREAL | 2012-05-02 | — | — | CN | disclosed |
| US-20080016627-A1 | Composition for dyeing of keratin fibers, comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, at least one oxidation base chosen from para-phenylenediamine and para-tolylenediamine, and a substituted meta-aminophenol | L'OREAL S.A. (FR) | 2008-01-24 | — | — | US | disclosed |
| US-20080016628-A1 | Composition for dyeing keratin fibers, comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 6-chloro-2-methyl-5-aminophenol and a substituted meta-aminophenol | L'OREAL S.A. (FR) | 2008-01-24 | — | — | US | disclosed |
| US-20080005853-A1 | Process for the predictable dyeing of keratinous fibers comprising applying at least one composition comprising at least one diamino-N, N-dihydropyrazolone derivative and at least one composition chosen from fundamental and/or golden-highlights compositions | L'OREAL S.A. (FR) | 2008-01-10 | — | — | US | disclosed |
| EP-1870083-A2 | Process for the predictable dyeing of keratinous fibres by application of a composition comprising a diamino-N,N-dihydropyrazolone derivative and of a fundamental or golden-highlights composition | L'Oréal (FR) | 2007-12-26 | — | — | EP | disclosed |
| EP-1870085-A2 | Composition for dyeing keratinous fibres comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, para-phenylenediamine or para-toluenediamine and a substituted meta-aminophenol | L'Oréal (FR) | 2007-12-26 | — | — | EP | disclosed |
| EP-1870084-A2 | Composition for dyeing keratin fibres comprising 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 6-chloro 2-methyl 5-aminophenol and a substituted meta-aminophenol | L'Oréal (FR) | 2007-12-26 | — | — | EP | disclosed |