Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.44 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30919983 | 1.00 | ALDH1A1 (0.49) | ALDH1A1HCAR3HCAR2FDPSGAA | |
| SCHEMBL17234135 | 1.00 | ALDH1A1 (0.49) | ALDH1A1HCAR3HCAR2FDPSGAA | |
| SCHEMBL17234143 | 1.00 | ALDH1A1 (0.49) | ALDH1A1HCAR3HCAR2FDPSGAA | |
| SCHEMBL30920017 | 1.00 | ALDH1A1 (0.49) | ALDH1A1HCAR3HCAR2FDPSGAA | |
| SCHEMBL23586876 | 0.88 | MME (0.46) | ALDH1A1FDPSGAAPOLBNPC1 | |
| SCHEMBL17234224 | 0.88 | MME (0.46) | ALDH1A1FDPSGAAPOLBNPC1 | |
| SCHEMBL17234229 | 0.88 | MME (0.46) | ALDH1A1FDPSGAAPOLBNPC1 | |
| SCHEMBL30919960 | 0.88 | MME (0.46) | ALDH1A1FDPSGAAPOLBNPC1 | |
| SCHEMBL17234138 | 0.85 | FDPS (0.46) | FDPSGAAPOLBNPC1RAB9A | |
| SCHEMBL30919966 | 0.85 | FDPS (0.46) | FDPSGAAPOLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016176636-A1 | INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF | RGENIX, INC. (US) | 2016-11-03 | — | — | WO | claimed |
| US-8394961-B2 | Method for the preparation of dabigatran | ZENTIVA K.S. (CZ) | 2013-03-12 | — | — | US | claimed |
| US-20110082299-A1 | METHOD FOR THE PREPARATION OF DABIGATRAN | ZENTIVA K.S. (CZ) | 2011-04-07 | — | — | US | claimed |
| EP-2262771-A1 | A METHOD FOR THE PREPARATION OF DABIGATRAN | Zentiva, K.S. (CZ) | 2010-12-22 | — | — | EP | claimed |
| WO-2009111997-A1 | A METHOD FOR THE PREPARATION OF DABIGATRAN | ZENTIVA, K.S. (CZ) | 2009-09-17 | — | — | WO | claimed |
| EP-3950673-A1 | INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF | Inspirna, Inc. (US) | 2022-02-09 | — | — | EP | disclosed |
| EP-3137447-B1 | INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF | RGENIX INC (US) | 2021-06-30 | — | — | EP | disclosed |
| US-10717704-B2 | Inhibitors of creatine transport and uses thereof | RGENIX, INC. (US) | 2020-07-21 | — | — | US | disclosed |
| US-20190315680-A1 | INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF | INSPIRNA, INC. | 2019-10-17 | — | — | US | disclosed |
| US-9688657-B2 | Synthesis of dabigatran | USV PRIVATE LIMITED (IN) | 2017-06-27 | — | — | US | disclosed |
| US-20160060248-A1 | SYNTHESIS OF DABIGATRAN | USV PRIVATE LIMITED (IN) | 2016-03-03 | — | — | US | disclosed |
| US-8394961-B2 | Method for the preparation of dabigatran | ZENTIVA K.S. (CZ) | 2013-03-12 | — | — | US | disclosed |
| US-20110082299-A1 | METHOD FOR THE PREPARATION OF DABIGATRAN | ZENTIVA K.S. (CZ) | 2011-04-07 | — | — | US | disclosed |
| EP-2262771-A1 | A METHOD FOR THE PREPARATION OF DABIGATRAN | Zentiva, K.S. (CZ) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009111997-A1 | A METHOD FOR THE PREPARATION OF DABIGATRAN | ZENTIVA, K.S. (CZ) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060248-A1 | SYNTHESIS OF DABIGATRAN | ESD, F2, PROC | ALDH1A1 309/4885HCAR3 979/4885HCAR2 1823/4885 |
| US-10717704-B2 | Inhibitors of creatine transport and uses thereof | CKMT1A; CKMT1B, SLC25A1, SLC2A1 | ALDH1A1 2023/4885HCAR3 1746/4885HCAR2 1693/4885 |
| US-20190315680-A1 | INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF | CKMT1A; CKMT1B, SLC25A1, SLC2A1 | ALDH1A1 2023/4885HCAR3 1746/4885HCAR2 1693/4885 |
| US-20110082299-A1 | METHOD FOR THE PREPARATION OF DABIGATRAN | PROC, VKORC1, VKORC1L1 | ALDH1A1 1100/4885HCAR3 660/4885HCAR2 1015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.