Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.62 |
| ▸ | HTR1D | P28221 | 2/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1878625 | 0.89 | HTR1D (0.60) | HTR1BHTR1DHTR1ABAZ2BMEN1 | |
| SCHEMBL24408396 | 0.87 | HTR1B (0.57) | HTR1BHTR1DHTR1ABAZ2BMEN1 | |
| SCHEMBL16026868 | 0.86 | HTR1A (0.58) | HTR1BHTR1DHTR1AMEN1KMT2A | |
| SCHEMBL16026823 | 0.86 | HTR1B (0.48) | HTR1BHTR1DHTR1AMEN1KMT2A | |
| SCHEMBL14880114 | 0.84 | HTR1B (0.65) | HTR1BHTR1DHTR1ABAZ2BMEN1 | |
| SCHEMBL2429520 | 0.82 | HTR1A (0.54) | HTR1BHTR1DHTR1ABAZ2BKMT2A | |
| SCHEMBL16026808 | 0.82 | SIRT1 (0.54) | HTR1BHTR1DHTR1ABAZ2BKMT2A | |
| SCHEMBL4899580 | 0.82 | HTR1A (0.54) | HTR1BHTR1DHTR1ABAZ2BKMT2A | |
| SCHEMBL11831865 | 0.82 | HTR1D (0.66) | HTR1BHTR1DBAZ2BMEN1KMT2A | |
| SCHEMBL7111545 | 0.82 | MTNR1A (0.57) | HTR1BHTR1DHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558447-B1 | 3-(HETEROARYL-AMINO)-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2014-09-17 | — | — | EP | disclosed |