Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | HTR1B | P28222 | 2/20 | 0.58 |
| ▸ | HTR1D | P28221 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | HTR1E | P28566 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RB1 | P06400 | 4/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4899580 | 0.86 | HTR1A (0.54) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL16026808 | 0.86 | SIRT1 (0.54) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL2429520 | 0.86 | HTR1A (0.54) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL16026816 | 0.86 | HTR1B (0.62) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL16026774 | 0.83 | HTR1B (0.51) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL14693721 | 0.83 | NR2E1 (0.56) | HTR1AHTR1BHTR1DRB1 | |
| SCHEMBL11845531 | 0.82 | SIRT1 (0.55) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL16026823 | 0.81 | HTR1B (0.48) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| Oxalic Acid SCHEMBL7540449 | 0.80 | HTR1B (0.66) | HTR1AHTR1BHTR1DDRD2DRD4 | |
| SCHEMBL7412705 | 0.79 | L3MBTL1 (0.51) | HTR1AHTR1BHTR1DKMT2ARB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558447-B1 | 3-(HETEROARYL-AMINO)-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2014-09-17 | — | — | EP | disclosed |