Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27763486 | 0.82 | HPRT1 (0.47) | PTPN22POLBHSD17B10CYP1A2USP2 | |
| SCHEMBL20398800 | 0.79 | PTPN22 (0.54) | PTPN22POLBHSD17B10CYP1A2USP2 | |
| SCHEMBL7296516 | 0.79 | PTPN22 (0.54) | PTPN22POLBHSD17B10CYP1A2USP2 | |
| SCHEMBL31356444 | 0.79 | PTPN22 (0.54) | PTPN22POLBHSD17B10CYP1A2USP2 | |
| SCHEMBL2221239 | 0.79 | PTPN22 (0.54) | PTPN22POLBHSD17B10CYP1A2USP2 | |
| SCHEMBL23499948 | 0.78 | PTPN22 (0.52) | PTPN22POLBHSD17B10CYP1A2USP2 | |
| SCHEMBL2513921 | 0.77 | HSD17B10 (0.46) | POLBHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8388759 | 0.76 | PTPN22 (0.50) | PTPN22POLBHSD17B10CYP1A2USP2 | |
| SCHEMBL5596944 | 0.76 | PTPN22 (0.50) | PTPN22POLBHSD17B10CYP1A2USP2 | |
| SCHEMBL23861627 | 0.76 | PTPN22 (0.50) | PTPN22POLBHSD17B10CYP1A2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919154-B2 | 1-(trifluoromethyl)naphthalene derivative | DIC CORPORATION (JP) | 2011-04-05 | — | — | US | disclosed |
| US-20100140547-A1 | 1-(TRIFLUOROMETHYL)NAPHTHALENE DERIVATIVE | DIC CORPORATION (JP) | 2010-06-10 | — | — | US | disclosed |
| US-7053057-B2 | A carbamate and amide compound containing piperidine, tetrahydroquinoline or tetrahydroisoquinoline ring; enzyme inhibitor | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-05-30 | — | — | US | disclosed |
| EP-1283827-A2 | CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-02-19 | — | — | EP | disclosed |
| US-20020061853-A1 | Caspase inhibtors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2002-05-23 | — | — | US | disclosed |
| WO-2001090070-A2 | CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2001-11-29 | — | — | WO | disclosed |
| US-6215021-B1 | TRIFLUOROMETHYL DIPHENYLSULFONIUM TRIFLATE DERIVATIVES | IDAHO RESEARCH FOUNDATION, INC. | 2001-04-10 | — | — | US | disclosed |
| US-5629406-A | AMINO ACID DERIVATIVES | SANKYO COMPANY, LIMITED (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0587311-A1 | Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1994-03-16 | — | — | EP | disclosed |
| US-4562286-A | Process for preparing methoxytrifluoromethylnaphthoic acid from dimethylnaphthalene | OCCIDENTAL CHEMICAL CORPORATION (US) | 1985-12-31 | — | — | US | disclosed |
| US-4560794-A | Process for preparing methoxytrifluoromethylnaphthoic acid from methylnaphthoic acid | OCCIDENTAL CHEMICAL CORPORATION (US) | 1985-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100140547-A1 | 1-(TRIFLUOROMETHYL)NAPHTHALENE DERIVATIVE | HVCN1, VIM, NES | PTPN22 1662/4885POLB 2640/4885HSD17B10 1350/4885 |
| US-20020061853-A1 | Caspase inhibtors and uses thereof | CASP2, CASP1, CASP3 | PTPN22 4809/4885POLB 4178/4885HSD17B10 376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.