Methylthioadenosine

Methylthioadenosine

SCHEMBL160358

CSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHCY P23526 7/20 0.83
NADK O95544 1/20 0.83
DOT1L Q8TEK3 3/20 0.74
DNMT3B Q9UBC3 2/20 0.74
ADORA3 P0DMS8 2/20 0.74
PNMT P11086 1/20 0.74
DNMT1 P26358 1/20 0.74
DPP4 P27487 1/20 0.74
MEN1 O00255 1/20 0.74
SLC28A1 O00337 1/20 0.74
MAP3K7 O43318 1/20 0.74
SLC28A2 O43868 1/20 0.74
GAPDH P04406 1/20 0.74
MAPK1 P28482 1/20 0.74
ADORA2A P29274 1/20 0.74
ADORA2B P29275 1/20 0.74
ADORA1 P30542 1/20 0.74
STAT6 P42226 1/20 0.74
PI4KA P42356 1/20 0.74
KMT2A Q03164 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylthioadenosine SCHEMBL29439558 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL20798030 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL29361072 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL890628 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL31388809 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL11954365 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL10013421 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL101382 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL7124285 0.95 DOT1L (0.78) AHCYNADKDOT1LDNMT3BPNMT
Methylthioadenosine SCHEMBL20817193 0.91 AHCY (0.70) AHCYNADKDOT1LDNMT3BADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2099 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
WO-2026107412-A1 SARCOSPAN MODULATION AND METHODS OF MEAT AND TISSUE CULTURE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-05-21 WO claimed
WO-2026088246-A1 METHOD FOR PRODUCING LOW-MOLECULAR-WEIGHT COMPOUND NTT株式会社 2026-04-30 WO claimed
WO-2025217007-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-10-16 WO claimed
WO-2025217008-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND SOS1 INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-10-16 WO claimed
WO-2025217015-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND KRAS G12D INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-10-16 WO claimed
US-20250312351-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND SOS1 INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-10-09 US claimed
US-20250312343-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND KRAS G12D INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-10-09 US claimed
US-20250312344-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-10-09 US claimed
EP-4580628-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND BCL-2 FAMILY INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-07-09 EP claimed
WO-1992007570-A1 AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES HEALTH RESEARCH, INC. (US) 1992-05-14 WO claimed
US-4973678-A VASODILATORS, ANALGESICS, ANTIINFLAMMATORY, ANTIPYRETIC, ANTICOAGULANTS NB JACKETS DE PUERTO RICO (US) 1990-11-27 US claimed
EP-0387756-A1 Use of 5'-deoxy-5'-methylthioadenosine s-adenosylmethionine and their salts in the preparation of seborrhea-reducing pharmaceutical compositions BIORESEARCH S.p.A. (IT) 1990-09-19 EP claimed
EP-0387757-A2 Use of 5'-deoxy-5'methylthioadenosine, S-adenosylmethionine and their salts in the preparation of pharmaceutical compositions favouring hair growth in subjects suffering from baldness BIORESEARCH S.p.A. (IT) 1990-09-19 EP claimed
US-4948783-A ORALLY ADMINISTERING ADENOSINE OR DERIVATIVE KABUSHIKI KAISYA ADVANCE KAIHATSU KENKYUJO (JP) 1990-08-14 US claimed
EP-0184248-B1 SALTS OF 5'-METHYLTHIO-5'-DEOXYADENOSINE WITH LONG-ALKYL CHAIN SULPHONIC ACIDS BIORESEARCH S.p.A. (IT) 1989-08-02 EP claimed
EP-0184248-A2 Salts of 5'-methylthio-5'-deoxyadenosine with long-alkyl chain sulphonic acids BIORESEARCH S.p.A. (IT) 1986-06-11 EP claimed
US-4562149-A CULTIVATING A MICROORGANISM IN LIQUID CULTURE MEDIUM CONTAINING METHIONINE NIPPON ZEON CO., LTD. (JP) 1985-12-31 US claimed
US-4373097-A Process for preparing adenosine derivatives of anti-inflammatory and analgesic activity BIORESEARCH S.R.L. (IT) 1983-02-08 US claimed
US-3962034-A CULTURE AJINOMOTO CO., INC. (JA) 1976-06-08 US claimed