Methylthioadenosine

Methylthioadenosine

SCHEMBL101382

CSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHCY P23526 7/20 0.83
NADK O95544 1/20 0.83
DOT1L Q8TEK3 3/20 0.74
DNMT3B Q9UBC3 2/20 0.74
ADORA3 P0DMS8 2/20 0.74
PNMT P11086 1/20 0.74
DNMT1 P26358 1/20 0.74
DPP4 P27487 1/20 0.74
MEN1 O00255 1/20 0.74
SLC28A1 O00337 1/20 0.74
MAP3K7 O43318 1/20 0.74
SLC28A2 O43868 1/20 0.74
GAPDH P04406 1/20 0.74
MAPK1 P28482 1/20 0.74
ADORA2A P29274 1/20 0.74
ADORA2B P29275 1/20 0.74
ADORA1 P30542 1/20 0.74
STAT6 P42226 1/20 0.74
PI4KA P42356 1/20 0.74
KMT2A Q03164 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylthioadenosine SCHEMBL29439558 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL20798030 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL160358 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL29361072 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL890628 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL31388809 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL11954365 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL10013421 1.00 AHCY (0.83) AHCYNADKDOT1LDNMT3BADORA3
Methylthioadenosine SCHEMBL7124285 0.95 DOT1L (0.78) AHCYNADKDOT1LDNMT3BPNMT
Methylthioadenosine SCHEMBL20817193 0.91 AHCY (0.70) AHCYNADKDOT1LDNMT3BADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144829-A1 SYNBIOTIC COMPOSITION, METABOLITES, AND METHOD OF PREVENTING AND TREATING OBESITY-RELATED DISEASE Hsu, Cheng-Chih (TW) 2026-05-28 US claimed
WO-2026088246-A1 METHOD FOR PRODUCING LOW-MOLECULAR-WEIGHT COMPOUND NTT株式会社 2026-04-30 WO claimed
US-20260051387-A1 METABOLOMIC ANALYSIS OF PERITONEAL DIALYSIS EFFLUENT FRESENIUS MEDICAL CARE HOLDINGS, INC. (US) 2026-02-19 US claimed
US-20250341515-A1 METABOLOMIC BIOMARKERS FOR ACUTE KIDNEY INJURY, ASSAYS, COMPOSITIONS AND METHODS OF USE THEREOF WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2025-11-06 US claimed
EP-4597111-A1 USE OF METABOLIC MARKER FOR DIAGNOSIS OF LUNG CANCER STAGING AND KIT Harbin Metanotitia Inc. (CN) 2025-08-06 EP claimed
WO-2025085615-A1 METHODS TO RAPIDLY DETECT METHYLTHIOADENOSINE AND RELATED METABOLITES DIRECTLY FROM PATIENT SAMPLES TO IDENTIFY 9P21 LOSS CANCERS AND TREATMENT STRATEGIES FOR PATIENTS BAYLOR COLLEGE OF MEDICINE (US) 2025-04-24 WO claimed
US-20240385183-A1 METABOLIC AND MICROBIAL BIOMARKERS FOR DETECTION OF PANCREATICOBILIARY CANCERS NORTHWESTERN UNIVERSITY 2024-11-21 US claimed
WO-2024230650-A1 SYNBIOTIC COMPOSITION, METABOLITE AND USE THEREOF IN PREVENTION AND TREATMENT OF OBESITY-RELATED DISEASES 徐丞志 2024-11-14 WO claimed
WO-2024152730-A1 BIOMARKERS FOR IDENTIFYING INFREQUENT GOUT FLARES AND FREQUENT GOUT FLARES AND USE THEREOF 苏州艾麦锶生命科技有限公司 2024-07-25 WO claimed
US-12018299-B2 Methods and kits for quantifying adenosine-containing molecules SEVIVO LLC (US) 2024-06-25 US claimed
EP-0505440-A4 GENETIC CONTROL OF ETHYLENE BIOSYNTHESIS IN PLANTS 1992-11-19 EP claimed
EP-0505440-A1 GENETIC CONTROL OF ETHYLENE BIOSYNTHESIS IN PLANTS AGRITOPE, INC. (US) 1992-09-30 EP claimed
WO-1992007570-A1 AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES HEALTH RESEARCH, INC. (US) 1992-05-14 WO claimed
WO-1991009112-A1 GENETIC CONTROL OF ETHYLENE BIOSYNTHESIS IN PLANTS AGRITOPE, INC. (US) 1991-06-27 WO claimed
US-4973678-A VASODILATORS, ANALGESICS, ANTIINFLAMMATORY, ANTIPYRETIC, ANTICOAGULANTS NB JACKETS DE PUERTO RICO (US) 1990-11-27 US claimed
EP-0387757-A2 Use of 5'-deoxy-5'methylthioadenosine, S-adenosylmethionine and their salts in the preparation of pharmaceutical compositions favouring hair growth in subjects suffering from baldness BIORESEARCH S.p.A. (IT) 1990-09-19 EP claimed
EP-0387756-A1 Use of 5'-deoxy-5'-methylthioadenosine s-adenosylmethionine and their salts in the preparation of seborrhea-reducing pharmaceutical compositions BIORESEARCH S.p.A. (IT) 1990-09-19 EP claimed
EP-0184248-B1 SALTS OF 5'-METHYLTHIO-5'-DEOXYADENOSINE WITH LONG-ALKYL CHAIN SULPHONIC ACIDS BIORESEARCH S.p.A. (IT) 1989-08-02 EP claimed
EP-0184248-A2 Salts of 5'-methylthio-5'-deoxyadenosine with long-alkyl chain sulphonic acids BIORESEARCH S.p.A. (IT) 1986-06-11 EP claimed
US-4373097-A Process for preparing adenosine derivatives of anti-inflammatory and analgesic activity BIORESEARCH S.R.L. (IT) 1983-02-08 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260144829-A1 SYNBIOTIC COMPOSITION, METABOLITES, AND METHOD OF PREVENTING AND TREATING OBESITY-RELATED DISEASE MLN, COMT, MLEC AHCY 77/4885NADK 2095/4885DOT1L 2329/4885
US-20260051387-A1 METABOLOMIC ANALYSIS OF PERITONEAL DIALYSIS EFFLUENT SLC43A1, SLC14A1, SLC1A5 AHCY 183/4885NADK 2614/4885DOT1L 3430/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.