Phendimetrazine

Phendimetrazine

SCHEMBL160375

C[C@H]1[C@H](c2ccccc2)OCCN1C.O=C(O)C(O)C(O)C(=O)O

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC6A2SLC6A3

The experimentally established mechanism targets of Phendimetrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 5/20 0.41
SLC6A3 known ✓ Q01959 5/20 0.41
HTR1A P08908 1/20 0.75
KDM4E B2RXH2 1/20 0.43
BLM P54132 1/20 0.43
ALOX15 P16050 1/20 0.43
HTR2B P41595 2/20 0.41
ADRA1A P35348 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.38
CYP2D6 P10635 4/20 0.38
SLC6A4 P31645 4/20 0.38
KCNH2 Q12809 3/20 0.38
CYP2C19 P33261 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.36
ACE P12821 2/20 0.36
MME P08473 1/20 0.36
POLB P06746 1/20 0.36
CHRM2 P08172 1/20 0.35
CHRM1 P11229 1/20 0.35
ADRA2B P18089 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phendimetrazine SCHEMBL29353044 1.00 HTR1A (0.75) HTR1AKDM4EBLMALOX15SLC6A2
Phendimetrazine SCHEMBL15064941 1.00 HTR1A (0.75) HTR1AKDM4EBLMALOX15SLC6A2
Phendimetrazine SCHEMBL29554688 1.00 HTR1A (0.75) HTR1AKDM4EBLMALOX15SLC6A2
Phendimetrazine SCHEMBL160376 1.00 HTR1A (0.75) HTR1AKDM4EBLMALOX15SLC6A2
Phendimetrazine SCHEMBL10613088 0.99 HTR1A (0.73) HTR1AKDM4EBLMALOX15SLC6A2
Phendimetrazine SCHEMBL21603017 0.88 HTR1A (0.57) HTR1AKDM4EBLMALOX15CYP2D6
Phendimetrazine SCHEMBL15064942 0.87 HTR1A (1.00) HTR1ASLC6A2SLC6A3HTR2BADRA1A
Phendimetrazine SCHEMBL49481 0.87 HTR1A (1.00) HTR1ASLC6A2SLC6A3HTR2BADRA1A
Phendimetrazine SCHEMBL344020 0.87 HTR1A (1.00) HTR1ASLC6A2SLC6A3HTR2BADRA1A
Phendimetrazine SCHEMBL598950 0.87 HTR1A (1.00) HTR1ASLC6A2SLC6A3HTR2BADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5615 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4654966-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF OBESITY AND DISEASES ASSOCIATED WITH FAT CELL ENLARGEMENT MELLICELL, INC. (US) 2025-12-03 EP claimed
US-12378579-B2 Method to produce the anti-microbial diterpenoid leubethanol and related serrulatane-type diterpenes BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2025-08-05 US claimed
WO-2025137653-A1 METHODS AND COMPOSITIONS OF POLYCYCLIC AND A DUAL ACTING NITROXIDE COMPOUNDS FOR TREATMENT OF FAT CELL ASSOCIATED DISEASES MELLICELL, INC. (US) 2025-06-26 WO claimed
US-20240282425-A1 AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS LOW GORDON KEITH (US) 2024-08-22 US claimed
WO-2024159211-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF OBESITY AND DISEASES ASSOCIATED WITH FAT CELL ENLARGEMENT MELLICELL, INC. (US) 2024-08-02 WO claimed
CN-117883438-A Method for treating malignant lymphoproliferative diseases 开动疗法公司 2024-04-16 CN claimed
US-11896598-B2 Appetite suppressant compositions and methods thereof Red Mountain Med Spa, LLC (US) 2024-02-13 US claimed
EP-2552202-B1 METHODS AND COMPOSITIONS FOR WEIGHT LOSS SDG INC (US) 2023-07-26 EP claimed
WO-2023126672-A1 METHOD AND DEVICE FOR REMOVAL OF CIRCULATING CELL FREE DNA SANTERSUS AG (CH) 2023-07-06 WO claimed
US-20230193328-A1 METHOD TO PRODUCE THE ANTI-MICROBIAL DITERPENOID LEUBETHANOL AND RELATED SERRULATANE-TYPE DITERPENES BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY 2023-06-22 US claimed
EP-1119345-A1 ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES GENERAL MILLS, INC. (US) 2001-08-01 EP claimed
CN-1267342-A Method and device for regulating concentration of substaces in electrolytes ATOTECH DEUTSCHLAND GMBH (DE) 2000-09-20 CN claimed
WO-2000021504-A1 ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES GENERAL MILLS, INC. (US) 2000-04-20 WO claimed
EP-0935523-A4 EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES GEN MILLS INC (US) 1999-12-29 EP claimed
EP-0935523-A1 EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES GENERAL MILLS, INC. (US) 1999-08-18 EP claimed
US-5795880-A Method and composition for treating obesity and related disorders in animals comprising dehydroepiandrosterone (DHEA), or a derivative thereof, and an anorectic agent LOUISIANA STATE UNIVERSITY MEDICAL CENTER FOUNDATION (US) 1998-08-18 US claimed
WO-1998018610-A1 EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES LENGERICH BERNHARD H VAN (US) 1998-05-07 WO claimed
US-5527788-A Method and composition for treating obesity comprising dehydroepiandrosterone (DHEA), or a derivative thereof, and an anorectic agent LOUISIANA STATE UNIV. MEDICAL CENTER FOUNDATION (US) 1996-06-18 US claimed
WO-1994000401-A1 METHOD FOR PRODUCING CONSTRUCTION DECORATIVE PRODUCTS AND/OR DECORATIVE CLADDING LOW WATER BINDER, S.A. (ES) 1994-01-06 WO claimed
CN-87106313-A The improvement of organic compound 1988-05-04 CN claimed