Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phendimetrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 6/20 | 0.33 |
| ▸ | DRD2 | P14416 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phendimetrazine SCHEMBL15064941 | 0.88 | HTR1A (0.75) | HTR1AGAAKDM4EBLMALOX15 | |
| Phendimetrazine SCHEMBL160375 | 0.88 | HTR1A (0.75) | HTR1AGAAKDM4EBLMALOX15 | |
| Phendimetrazine SCHEMBL160376 | 0.88 | HTR1A (0.75) | HTR1AGAAKDM4EBLMALOX15 | |
| Phendimetrazine SCHEMBL29554688 | 0.88 | HTR1A (0.75) | HTR1AGAAKDM4EBLMALOX15 | |
| Phendimetrazine SCHEMBL29353044 | 0.88 | HTR1A (0.75) | HTR1AGAAKDM4EBLMALOX15 | |
| Phendimetrazine SCHEMBL10613088 | 0.86 | HTR1A (0.73) | HTR1AGAAKDM4EBLMALOX15 | |
| Phendimetrazine SCHEMBL2522887 | 0.76 | HTR1A (0.54) | HTR1AKDM4EBLMALOX15TSHR | |
| Phendimetrazine SCHEMBL4394730 | 0.76 | HTR1A (0.68) | HTR1ANPSR1GAAKDM4EDRD2 | |
| Phendimetrazine SCHEMBL49481 | 0.76 | HTR1A (1.00) | HTR1ADRD2TSHRCYP2D6CYP2C19 | |
| Phendimetrazine SCHEMBL344020 | 0.76 | HTR1A (1.00) | HTR1ADRD2TSHRCYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020022356-A1 | THERMOPLASTIC COMPOSITION AND MOLDED ARTICLE THEREOF | 大阪ガスケミカル株式会社 | 2020-01-30 | — | — | WO | disclosed |
| WO-2020004416-A1 | ORGANIC-RESIN-COATED SHAPED METALLIC MATERIAL AND PRODUCTION METHOD THEREFOR | 日鉄日新製鋼株式会社 | 2020-01-02 | — | — | WO | disclosed |