Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phendimetrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phendimetrazine SCHEMBL15064941 | 1.00 | HTR1A (0.75) | HTR1AKDM4EBLMALOX15SLC6A2 | |
| Phendimetrazine SCHEMBL29554688 | 1.00 | HTR1A (0.75) | HTR1AKDM4EBLMALOX15SLC6A2 | |
| Phendimetrazine SCHEMBL160376 | 1.00 | HTR1A (0.75) | HTR1AKDM4EBLMALOX15SLC6A2 | |
| Phendimetrazine SCHEMBL160375 | 1.00 | HTR1A (0.75) | HTR1AKDM4EBLMALOX15SLC6A2 | |
| Phendimetrazine SCHEMBL10613088 | 0.99 | HTR1A (0.73) | HTR1AKDM4EBLMALOX15SLC6A2 | |
| Phendimetrazine SCHEMBL21603017 | 0.88 | HTR1A (0.57) | HTR1AKDM4EBLMALOX15CYP2D6 | |
| Phendimetrazine SCHEMBL15064942 | 0.87 | HTR1A (1.00) | HTR1ASLC6A2SLC6A3HTR2BADRA1A | |
| Phendimetrazine SCHEMBL49481 | 0.87 | HTR1A (1.00) | HTR1ASLC6A2SLC6A3HTR2BADRA1A | |
| Phendimetrazine SCHEMBL344020 | 0.87 | HTR1A (1.00) | HTR1ASLC6A2SLC6A3HTR2BADRA1A | |
| Phendimetrazine SCHEMBL598950 | 0.87 | HTR1A (1.00) | HTR1ASLC6A2SLC6A3HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1017 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630262-B2 | Inflatable boat with a drop stitch bottom for use with a motor | VARGA KRISTOFER GEORGE (CA) | 2026-05-19 | — | — | US | claimed |
| EP-4724537-A1 | COATING RESISTANT TO BIOGROWTH PARTICULARLY IN MARINE ENVIRONMENTS | Core Industries II, LLC (US) | 2026-04-15 | — | — | EP | claimed |
| US-12565290-B1 | System and method for controlling heading of a marine vessel having trim tabs | BRUNSWICK CORPORATION (US) | 2026-03-03 | — | — | US | claimed |
| US-12539948-B2 | Devices, systems, and methods for alerting users on a watercraft | NAVICO, INC. (US) | 2026-02-03 | — | — | US | claimed |
| US-20260001632-A1 | SYSTEMS AND METHODS FOR CONTROLLING A WAKE BEHIND A WATERCRAFT | NAVICO GROUP AMERICAS LLC (US) | 2026-01-01 | — | — | US | claimed |
| US-12454931-B2 | Vertical intermingling of deep water | BARBER GERALD L (US) | 2025-10-28 | — | — | US | claimed |
| US-12429870-B1 | Marine steering system and method | BRUNSWICK CORPORATION (US) | 2025-09-30 | — | — | US | claimed |
| US-20250223939-A1 | VERTICAL INTERMINGLING OF DEEP WATER | BARBER GERALD L (US) | 2025-07-10 | — | — | US | claimed |
| US-20250178711-A1 | MARINE VESSEL BRAKE ASSIST AND STABILIZATION SYSTEM | NAIAD MARITIME GROUP, INC. | 2025-06-05 | — | — | US | claimed |
| US-12312052-B1 | Systems and methods for controlling marine vessels based on seat occupancy | BRUNSWICK CORPORATION (US) | 2025-05-27 | — | — | US | claimed |
| US-11459063-B2 | System and method of a modified trim tab system with fluid hinge for variable-transom watercrafts | LANGLOIS JOSEPH R (US) | 2022-10-04 | — | — | US | claimed |
| US-20220213871-A1 | DUCTED WIND TURBINE AND SUPPORT PLATFORM | SEAMACH LTD (GB) | 2022-07-07 | — | — | US | claimed |
| US-11372411-B1 | Marine steering system and method | BRUNSWICK CORPORATION (US) | 2022-06-28 | — | — | US | claimed |
| US-20220169339-A1 | MULTIHULL WATERCRAFT | BOMBARDIER RECREATIONAL PRODUCTS INC. (CA) | 2022-06-02 | — | — | US | claimed |
| WO-2022109463-A1 | REMOTE CONTROL VEHICLE WITH NEON LIGHTS | WeCool Toys Inc. (US) | 2022-05-27 | — | — | WO | claimed |
| US-20220161149-A1 | REMOTE CONTROL VEHICLE WITH NEON LIGHTS | MIDCAP FINANCIAL TRUST, AS COLLATERAL AGENT | 2022-05-26 | — | — | US | claimed |
| WO-2022094121-A1 | MARINE VESSEL BRAKE ASSIST AND STABILIZATION SYSTEM | NAIAD MARITIME GROUP, INC. (US) | 2022-05-05 | — | — | WO | claimed |
| US-20220126972-A1 | Marine Vessel Brake Assist And Stabilization System | NAIAD MARITIME GROUP, INC. | 2022-04-28 | — | — | US | claimed |
| US-11254391-B2 | Ballast system for a boat and method of operating a boat | MASTERCRAFT BOAT COMPANY, LLC (US) | 2022-02-22 | — | — | US | claimed |
| US-20220047958-A1 | AERODYNAMICALLY GLIDING BALL | REAL RADICAL FLIGHT LLC (US) | 2022-02-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12565290-B1 | System and method for controlling heading of a marine vessel having trim tabs | YEATS2, YEATS4, TAB1 | SLC6A2 312/4885SLC6A3 603/4885HTR1A 578/4885 |
| US-12539948-B2 | Devices, systems, and methods for alerting users on a watercraft | CASR, STING1, NCS1 | SLC6A2 1848/4885SLC6A3 2444/4885HTR1A 2800/4885 |
| US-12630262-B2 | Inflatable boat with a drop stitch bottom for use with a motor | YEATS2, MUSK, MYLK2 | SLC6A2 966/4885SLC6A3 452/4885HTR1A 943/4885 |
| US-20260001632-A1 | SYSTEMS AND METHODS FOR CONTROLLING A WAKE BEHIND A WATERCRAFT | WAPL, IWS1, WDR48 | SLC6A2 432/4885SLC6A3 1020/4885HTR1A 1932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.