Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phendimetrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phendimetrazine SCHEMBL29353044 | 1.00 | HTR1A (0.75) | HTR1AKDM4EBLMALOX15SLC6A2 | |
| Phendimetrazine SCHEMBL15064941 | 1.00 | HTR1A (0.75) | HTR1AKDM4EBLMALOX15SLC6A2 | |
| Phendimetrazine SCHEMBL29554688 | 1.00 | HTR1A (0.75) | HTR1AKDM4EBLMALOX15SLC6A2 | |
| Phendimetrazine SCHEMBL160375 | 1.00 | HTR1A (0.75) | HTR1AKDM4EBLMALOX15SLC6A2 | |
| Phendimetrazine SCHEMBL10613088 | 0.99 | HTR1A (0.73) | HTR1AKDM4EBLMALOX15SLC6A2 | |
| Phendimetrazine SCHEMBL21603017 | 0.88 | HTR1A (0.57) | HTR1AKDM4EBLMALOX15CYP2D6 | |
| Phendimetrazine SCHEMBL15064942 | 0.87 | HTR1A (1.00) | HTR1ASLC6A2SLC6A3HTR2BADRA1A | |
| Phendimetrazine SCHEMBL49481 | 0.87 | HTR1A (1.00) | HTR1ASLC6A2SLC6A3HTR2BADRA1A | |
| Phendimetrazine SCHEMBL344020 | 0.87 | HTR1A (1.00) | HTR1ASLC6A2SLC6A3HTR2BADRA1A | |
| Phendimetrazine SCHEMBL598950 | 0.87 | HTR1A (1.00) | HTR1ASLC6A2SLC6A3HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1010 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122043215-A | FPGA aging monitoring method and system based on partition weighting RO array | 中科芯磁科技(珠海)有限责任公司 | 2026-05-15 | — | — | CN | claimed |
| CN-120145114-A | Equipment life prediction method based on multi-level analysis and sequential evaluation method | 哈尔滨工业大学 | 2025-06-13 | — | — | CN | claimed |
| CN-118629063-B | Financial bill analysis method and system based on image recognition technology | 深圳广宏盈信网络科技有限公司 | 2025-04-04 | — | — | CN | claimed |
| CN-117451054-B | Unmanned aerial vehicle high-precision indoor positioning method based on monocular camera, IMU and UWB multi-sensor fusion | 合肥工业大学 | 2025-01-07 | — | — | CN | claimed |
| CN-117275215-B | Urban road congestion space-time prediction method based on graph process neural network | 长江空间信息技术工程有限公司(武汉) | 2024-11-19 | — | — | CN | claimed |
| CN-118941719-A | Space three-dimensional model data loading method and system and electronic equipment | 河北省自然资源信息中心 | 2024-11-12 | — | — | CN | claimed |
| CN-118629063-A | Financial bill analysis method and system based on image recognition technology | 深圳广宏盈信网络科技有限公司 | 2024-09-10 | — | — | CN | claimed |
| CN-118484597-A | Part manufacturing and assembling outline recommending platform and recommending method based on user feedback | 中国商用飞机有限责任公司北京民用飞机技术研究中心 | 2024-08-13 | — | — | CN | claimed |
| CN-114590995-B | Borosilicate glass articles | 肖特股份有限公司 | 2024-07-12 | — | — | CN | claimed |
| CN-118213994-A | Distributed energy global coordination and collaborative autonomous regulation recovery strategy method and device | 国网北京市电力公司 | 2024-06-18 | — | — | CN | claimed |
| US-20030119428-A1 | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors | SCHERING CORPORATION | 2003-06-26 | — | — | US | claimed |
| US-20020044968-A1 | High amount of plasticizer to facilitate plasticization of the matrix material at low shear and then reduced prior to adding the encapsulant to reduce post extrusion | GENERAL MILLS, INC. | 2002-04-18 | — | — | US | claimed |
| JP-2002511777-A | — | — | 2002-04-16 | — | — | JP | claimed |
| EP-1119345-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2001-08-01 | — | — | EP | claimed |
| WO-2000021504-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2000-04-20 | — | — | WO | claimed |
| EP-0935523-A4 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GEN MILLS INC (US) | 1999-12-29 | — | — | EP | claimed |
| EP-0935523-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GENERAL MILLS, INC. (US) | 1999-08-18 | — | — | EP | claimed |
| US-5795880-A | Method and composition for treating obesity and related disorders in animals comprising dehydroepiandrosterone (DHEA), or a derivative thereof, and an anorectic agent | LOUISIANA STATE UNIVERSITY MEDICAL CENTER FOUNDATION (US) | 1998-08-18 | — | — | US | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| US-5527788-A | Method and composition for treating obesity comprising dehydroepiandrosterone (DHEA), or a derivative thereof, and an anorectic agent | LOUISIANA STATE UNIV. MEDICAL CENTER FOUNDATION (US) | 1996-06-18 | — | — | US | claimed |