Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16046050 | 0.94 | TSHR (0.64) | TSHRSMN1; SMN2HSD11B1CYP2D6POLB | |
| Benzoic Acid SCHEMBL16048080 | 0.90 | TSHR (0.50) | TSHRSMN1; SMN2HSD11B1CYP2D6POLB | |
| Benzoic Acid SCHEMBL16046029 | 0.84 | TSHR (0.52) | TSHRSMN1; SMN2HSD11B1CYP2D6POLB | |
| SCHEMBL28132172 | 0.82 | TSHR (0.70) | TSHRSMN1; SMN2HSD11B1CYP2D6POLB | |
| SCHEMBL2057214 | 0.81 | TSHR (0.57) | TSHRSMN1; SMN2HSD11B1CYP2D6POLB | |
| SCHEMBL10482034 | 0.81 | CA2 (0.56) | HSD11B1POLBCYP2C19CA2PSIP1 | |
| Chloromethane SCHEMBL27977129 | 0.81 | TSHR (0.84) | TSHRSMN1; SMN2HSD11B1CYP2D6POLB | |
| SCHEMBL8374928 | 0.81 | TSHR (0.94) | TSHRSMN1; SMN2CYP2D6POLBCYP2C19 | |
| SCHEMBL9465139 | 0.80 | CA2 (0.54) | HSD11B1POLBCYP2C19CA2PSIP1 | |
| Propane SCHEMBL28882618 | 0.79 | TSHR (0.80) | TSHRSMN1; SMN2HSD11B1CYP2D6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2969201-B1 | NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS | FORMOSA PLASTICS CORP USA (US) | 2022-05-04 | — | — | EP | disclosed |
| US-9790291-B2 | Non-phthalate compounds as electron donors for polyolefin catalysts | FORMOSA PLASTICS CORPORATION, USA (US) | 2017-10-17 | — | — | US | disclosed |
| EP-2969201-A2 | NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS | Formosa Plastics Corporation, U.S.A. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014160012-A2 | NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS | FORMOSA PLASTICS CORPORATION, USA (US) | 2014-10-02 | — | — | WO | disclosed |
| US-20140275456-A1 | NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS | FORMOSA PLASTICS CORPORATION, USA (US) | 2014-09-18 | — | — | US | disclosed |