Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.57 |
| ▸ | NPY4R | P50391 | 14/20 | 0.48 |
| ▸ | NPY1R | P25929 | 8/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.48 |
| ▸ | NPY2R | P49146 | 5/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15987249 | 1.00 | SIRT5 (0.57) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL24900018 | 0.94 | SIRT5 (0.49) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL1934309 | 0.94 | SIRT5 (0.49) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL29626768 | 0.93 | SIRT6 (0.57) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL31024641 | 0.93 | SIRT6 (0.57) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL13701341 | 0.92 | SIRT5 (0.63) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL18264843 | 0.92 | SIRT5 (0.50) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL22791266 | 0.92 | SIRT5 (0.50) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL24306611 | 0.91 | NPY4R (0.57) | SIRT5NPY4RNPY1RNPY5RNPY2R | |
| SCHEMBL17950964 | 0.91 | NPY4R (0.57) | SIRT5NPY4RNPY1RNPY5RNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970415-B1 | APELIN FUSION PROTEINS AND USES THEREOF | REGENERON PHARMA (US) | 2018-12-19 | — | — | EP | disclosed |
| US-20180030099-A1 | Apelin Fusion Proteins and Uses Thereof | REGENERON PHARMACEUTICALS, INC. | 2018-02-01 | — | — | US | disclosed |
| US-9751921-B2 | Apelin fusion proteins and uses thereof | REGENERON PHARMACEUTICALS, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-20160237130-A1 | Apelin Fusion Proteins and Uses Thereof | REGENERON PHARMACEUTICALS, INC. | 2016-08-18 | — | — | US | disclosed |
| US-9353163-B2 | Apelin fusion proteins and uses thereof | REGENERON PHARMACEUTICALS, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| EP-2970415-A1 | APELIN FUSION PROTEINS AND USES THEREOF | Regeneron Pharmaceuticals, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| CN-105026423-A | Apelin fusion proteins and uses thereof | REGENERON PHARMA | 2015-11-04 | — | — | CN | disclosed |
| WO-2014152955-A1 | APELIN FUSION PROTEINS AND USES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| US-20140275489-A1 | APELIN FUSION PROTEINS AND USES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | US | disclosed |