SCHEMBL16047481

SCHEMBL16047481

O=C(CCCSSc1ccccn1)ON1C(=O)CC(S(=O)(=O)O)C1=O

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 18/20 0.36
HDAC4 P56524 11/20 0.36
HDAC6 Q9UBN7 5/20 0.36
HDAC2 Q92769 7/20 0.34
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5485914 0.94 ALDH1A1 (0.36) HDAC1HDAC4HDAC6HDAC2ALDH1A1
SCHEMBL30367749 0.94 ALDH1A1 (0.36) HDAC1HDAC4HDAC6HDAC2ALDH1A1
SCHEMBL5051961 0.91 HDAC1 (0.33) HDAC1HDAC4HDAC6HDAC2ALDH1A1
SCHEMBL29361373 0.89 HPGD (0.37) HDAC1HDAC4HDAC6HDAC2ALDH1A1
SCHEMBL44111 0.89 HPGD (0.37) HDAC1HDAC4HDAC6HDAC2ALDH1A1
SCHEMBL2033142 0.86 ALDH1A1 (0.45) ALDH1A1
SCHEMBL12056754 0.86 HPGD (0.32) HDAC1HDAC4HDAC6HDAC2
SCHEMBL19713428 0.86 HPGD (0.35) HDAC1HDAC4HDAC6HDAC2
SCHEMBL12056750 0.86 HPGD (0.36) HDAC1HDAC4HDAC6HDAC2
SCHEMBL2169209 0.84 LMNA (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10172875-B2 Therapeutic combinations comprising anti-FOLR1 immunoconjugates IMMUNOGEN, INC. (US) 2019-01-08 US claimed
CN-113039191-B Nucleotide analogues 奇异基因组学系统公司 2024-07-16 CN disclosed
US-11691982-B2 Thailanstatin analogs PH PHARMA CO., LTD. (KR) 2023-07-04 US disclosed
US-20200407369-A1 THAILANSTATIN ANALOGS PH PHARMA CO., LTD. (KR) 2020-12-31 US disclosed
US-10815246-B2 Thailanstatin analogs PH PHARMA CO., LTD. (KR) 2020-10-27 US disclosed
EP-3684773-A1 THAILANSTATIN ANALOGS pH Pharma Co., Ltd. (KR) 2020-07-29 EP disclosed
US-20200216463-A1 THAILANSTATIN ANALOGS PH PHARMA CO., LTD. (KR) 2020-07-09 US disclosed
US-20190233430-A1 THAILANSTATIN ANALOGS PH PHARMA CO., LTD. (KR) 2019-08-01 US disclosed
US-10301319-B2 Thailanstatin analogs PH PHARMA CO., LTD. (KR) 2019-05-28 US disclosed
WO-2019060398-A1 THAILANSTATIN ANALOGS PH PHARMA CO., LTD. (KR) 2019-03-28 WO disclosed
US-20170035905-A1 ANTIBODY DRUG CONJUGATES NOVARTIS AG (CH) 2017-02-09 US disclosed
US-20170035905-A1 ANTIBODY DRUG CONJUGATES NOVARTIS AG (CH) 2017-02-09 US disclosed
WO-2016188932-A2 COMBINATION COMPOSITIONS AND THEIR USE IN METHODS FOR TREATING OBESITY AND OBESITY-RELATED DISORDERS Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) 2016-12-01 WO disclosed
US-9498543-B2 Antibody drug conjugates NOVARTIS AG (CH) 2016-11-22 US disclosed
US-9498543-B2 Antibody drug conjugates NOVARTIS AG (CH) 2016-11-22 US disclosed
US-20160030594-A1 ANTIBODY DRUG CONJUGATES NOVARTIS AG (CH) 2016-02-04 US disclosed
US-20150320880-A1 ANTIBODY DRUG CONJUGATES NOVARTIS AG (CH) 2015-11-12 US disclosed
WO-2014150937-A1 ANTIBODY DRUG CONJUGATES NOVARTIS AG (CH) 2014-09-25 WO disclosed
US-20140271688-A1 ANTIBODY DRUG CONJUGATES IRM LLC (BM) 2014-09-18 US disclosed
US-20140271688-A1 ANTIBODY DRUG CONJUGATES IRM LLC (BM) 2014-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190233430-A1 THAILANSTATIN ANALOGS CD47, SUGT1, TPT1 HDAC1 3176/4885HDAC4 2266/4885HDAC6 118/4885
US-20160030594-A1 ANTIBODY DRUG CONJUGATES EPCAM, CD44, ABL1 HDAC1 1738/4885HDAC4 755/4885HDAC6 26/4885
US-10815246-B2 Thailanstatin analogs CD47, SUGT1, TPT1 HDAC1 3176/4885HDAC4 2266/4885HDAC6 118/4885
US-10301319-B2 Thailanstatin analogs CD47, SUGT1, TPT1 HDAC1 3176/4885HDAC4 2266/4885HDAC6 118/4885
US-20200216463-A1 THAILANSTATIN ANALOGS CD47, SUGT1, TPT1 HDAC1 3176/4885HDAC4 2266/4885HDAC6 118/4885
US-20200407369-A1 THAILANSTATIN ANALOGS CD47, SUGT1, TPT1 HDAC1 3176/4885HDAC4 2266/4885HDAC6 118/4885
US-20140271688-A1 ANTIBODY DRUG CONJUGATES EPCAM, CD44, ABL1 HDAC1 1738/4885HDAC4 755/4885HDAC6 26/4885
US-11691982-B2 Thailanstatin analogs CD47, SUGT1, TPT1 HDAC1 3176/4885HDAC4 2266/4885HDAC6 118/4885
US-20150320880-A1 ANTIBODY DRUG CONJUGATES EPCAM, CD44, ABL1 HDAC1 1738/4885HDAC4 755/4885HDAC6 26/4885
US-10172875-B2 Therapeutic combinations comprising anti-FOLR1 immunoconjugates FOLR1, FOLR2, DHFR HDAC1 4208/4885HDAC4 4196/4885HDAC6 2849/4885
US-20170035905-A1 ANTIBODY DRUG CONJUGATES EPCAM, CD44, ABL1 HDAC1 1738/4885HDAC4 755/4885HDAC6 26/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.