Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | FDPS | P14324 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1609108 | 0.93 | TACR2 (0.75) | TACR2KDM4ELMNAALDH1A1HTR1A | |
| SCHEMBL662145 | 0.93 | TACR2 (0.75) | TACR2KDM4ELMNAALDH1A1HTR1A | |
| SCHEMBL14856161 | 0.92 | TACR2 (0.56) | TACR2KDM4ELMNAALDH1A1HTR1A | |
| SCHEMBL5216691 | 0.91 | TACR2 (0.57) | TACR2KDM4ELMNAALDH1A1HTR1A | |
| SCHEMBL23006056 | 0.91 | TACR2 (0.57) | TACR2KDM4ELMNAALDH1A1HTR1A | |
| SCHEMBL19658009 | 0.90 | FDPS (0.65) | TACR2LMNAALDH1A1HPGDMAPT | |
| SCHEMBL4621810 | 0.88 | TACR2 (0.60) | TACR2KDM4ELMNAALDH1A1HTR1A | |
| SCHEMBL11734711 | 0.88 | TACR2 (0.60) | TACR2KDM4ELMNAALDH1A1HTR1A | |
| SCHEMBL15952102 | 0.87 | TACR2 (0.60) | TACR2KDM4ELMNAALDH1A1HTR1A | |
| SCHEMBL21427052 | 0.87 | TACR2 (0.52) | TACR2KDM4ELMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10188746-B2 | Pyrrolobenzodiazepines and conjugates thereof | MEDIMMUNE LIMITED (GB) | 2019-01-29 | — | — | US | disclosed |
| EP-2968585-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LTD (GB) | 2018-07-18 | — | — | EP | disclosed |
| US-20170340752-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LIMITED (GB) | 2017-11-30 | — | — | US | disclosed |
| EP-3193940-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | Medimmune Limited (GB) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016037644-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LIMITED (GB) | 2016-03-17 | — | — | WO | disclosed |
| US-20160031887-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN LIMITED (GB) | 2016-02-04 | — | — | US | disclosed |
| EP-2968585-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LIMITED (GB) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014140174-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN SÀRL (CH) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10188746-B2 | Pyrrolobenzodiazepines and conjugates thereof | CD22, GABRA1, CCNB1 | TACR2 122/4885KDM4E 3120/4885LMNA 983/4885 |
| US-20160031887-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | GABRA3, GABRA4, AVPR1B | TACR2 96/4885KDM4E 2450/4885LMNA 2301/4885 |
| US-20170340752-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | CD22, GABRA1, CCNB1 | TACR2 122/4885KDM4E 3120/4885LMNA 983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.