Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | GGH | Q92820 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.47 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14729264 | 1.00 | NAALAD2 (0.52) | NAALAD2GAAEPHX2GGHCA2 | |
| SCHEMBL27883413 | 0.89 | KMT2A (0.53) | EPHX2CA2KDM4ECA1KMT2A | |
| SCHEMBL27883407 | 0.89 | KMT2A (0.53) | EPHX2CA2KDM4ECA1KMT2A | |
| SCHEMBL27883399 | 0.85 | EPHX2 (0.50) | GAAEPHX2KDM4EKMT2AMAPT | |
| SCHEMBL12984806 | 0.84 | PTGS2 (0.51) | EPHX2KDM4EKMT2AMAPTHTT | |
| SCHEMBL27900720 | 0.84 | PTGS2 (0.51) | EPHX2KDM4EKMT2AMAPTHTT | |
| SCHEMBL19360027 | 0.83 | FOLH1 (0.61) | EPHX2FOLH1SMN1; SMN2 | |
| SCHEMBL19361040 | 0.83 | FOLH1 (0.64) | FOLH1 | |
| SCHEMBL2331560 | 0.83 | PSMB5 (0.49) | EPHX2KDM4EKMT2AHTTSMN1; SMN2 | |
| SCHEMBL20341502 | 0.83 | KDM4E (0.51) | EPHX2KDM4EKMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200190097-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2020-06-18 | — | — | US | claimed |
| US-10611767-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-04-07 | — | — | US | claimed |
| US-20180346474-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-12-06 | — | — | US | claimed |
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-19 | — | — | US | claimed |
| EP-2995199-B1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | UNIV HOLY GHOST DUQUESNE (US) | 2018-03-14 | — | — | EP | claimed |
| US-20170114066-A1 | Selective Proton Coupled Folate Transporter and Folate Receptor, and Garftase Inhibitor Compounds and Methods of Using the Same | WAYNE STATE UNIVERSITY | 2017-04-27 | — | — | US | claimed |
| US-9511069-B2 | Selective proton coupled folate transporter and folate receptor, and GRAFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2016-12-06 | — | — | US | claimed |
| EP-2995199-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | Duquesne University of The Holy Spirit (US) | 2016-03-16 | — | — | EP | claimed |
| EP-2348843-B1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | UNIV HOLY GHOST DUQUESNE (US) | 2015-11-11 | — | — | EP | claimed |
| EP-2627332-A2 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | Duquesne University of The Holy Spirit (US) | 2013-08-21 | — | — | EP | claimed |
| US-20120295926-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2012-11-22 | — | — | US | claimed |
| WO-2012051105-A2 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2012-04-19 | — | — | WO | claimed |
| EP-2348843-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | Duquesne University of the Holy Ghost (US) | 2011-08-03 | — | — | EP | claimed |
| US-20110082158-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-07 | — | — | US | claimed |
| WO-2010039792-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2010-04-08 | — | — | WO | claimed |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | claimed |
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-07-06 | — | — | US | disclosed |
| US-20210032286-A1 | PSMA Imaging Agents | SIEMENS MEDICAL SOLUTIONS USA, INC. | 2021-02-04 | — | — | US | disclosed |
| WO-2010039792-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2010-04-08 | — | — | WO | disclosed |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | NAALAD2 2350/4885GAA 686/4885EPHX2 1792/4885 |
| US-10611767-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | NAALAD2 2350/4885GAA 686/4885EPHX2 1792/4885 |
| US-20200190097-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | NAALAD2 2350/4885GAA 686/4885EPHX2 1792/4885 |
| US-20170114066-A1 | Selective Proton Coupled Folate Transporter and Folate Receptor, and Garftase Inhibitor Compounds and Methods of Using the Same | SLC46A1, SLC19A1, FOLR1 | NAALAD2 2350/4885GAA 686/4885EPHX2 1792/4885 |
| US-20110082158-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, FOLR2, FOLR1 | NAALAD2 1529/4885GAA 669/4885EPHX2 875/4885 |
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | NAALAD2 2350/4885GAA 686/4885EPHX2 1792/4885 |
| US-20210032286-A1 | PSMA Imaging Agents | FOLH1, KLK3, PSMA2 | NAALAD2 31/4885GAA 125/4885EPHX2 3034/4885 |
| US-20120295926-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | NAALAD2 2350/4885GAA 686/4885EPHX2 1792/4885 |
| US-20180346474-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | NAALAD2 2350/4885GAA 686/4885EPHX2 1792/4885 |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | NAALAD2 2350/4885GAA 686/4885EPHX2 1792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.