Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16059291 | 0.83 | MET (0.35) | METKDM4EGCKRAB9AKDR | |
| SCHEMBL5157570 | 0.79 | MAPK14 (0.43) | METAXLRAB9A | |
| SCHEMBL1136834 | 0.73 | MET (0.64) | METAXLKDR | |
| SCHEMBL2588943 | 0.73 | MET (0.36) | METKDM4EAXLRAB9AKDR | |
| SCHEMBL139115 | 0.69 | MET (0.46) | METAXLKDR | |
| SCHEMBL14975674 | 0.66 | MET (0.38) | METAXLKDR | |
| SCHEMBL3006765 | 0.66 | MET (0.43) | METALOX5APFEN1AXLGCK | |
| SCHEMBL138222 | 0.66 | MET (0.35) | METAXLGCKKDR | |
| SCHEMBL5154071 | 0.66 | MET (0.41) | METKDR | |
| SCHEMBL1137504 | 0.65 | MET (0.69) | METAXLKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737451-B1 | MONOCYCLIC HETEROCYCLES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-02-23 | — | — | EP | disclosed |